Protein Alignment nAChRalpha6 and LOC1268935

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: XP_307512.4
• Gene: LOC1268935 / 1268935
• VectorBaseID: AGAMI1_005560
• Length: 424
• Species: Anopheles gambiae
• Alignment Length: 536
• Identity: 97/536 - (18%)
• Similarity: 191/536 - (35%)
• Gaps: 177/536 - (33%)

  Fly     8 SLSLFVLLIFLAIIKESCQGPH--EKR------LLNHLL-STYNTLERPVANESEPLEVKFGLTL 63
            |||...|.:.:|.:.:|....:  :||      :..||. :.|:...||..:|.:.:.:.....|
Mosquito     4 SLSFIYLPLLVAFLFDSASSINCDKKRDNVQYTIKQHLFCNGYDPKIRPAKSEFDSINITTYAVL 68

  Fly    64 QQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDG 128
            .. .|:.|...:::......:.|.|.:|.||.:::..:..|.|..:::|.|.....||..||...
Mosquito    69 YS-FDISEYRSVMSFQVNYYMRWQDSSLAWNASDWSNITTLNINNDEIWSPQFENINSDYEGQPS 132

  Fly   129 T--YHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDG 191
            .  .:.:.:::.||.....|.....:.|..|.:.:||:...|.|    | :.....:||    |.
Mosquito   133 VSCLNPDCLLRVNGYVSCSPVCRISAKCSSDYSRWPFNTLVCRM----W-FTNRDKELV----DE 188

  Fly   192 GDLSDFIT---------NGEWYL---------LAMPGKKNTIVYACCPEPYVDITFTIQIRRRTL 238
            .:....||         ..:|.:         |::||..:..|        .::.|.::
Mosquito   189 VNFLPVITYLPSNRHLPTTKWCVTSISSNKTQLSIPGATSRTV--------EELEFNLE------ 239

  Fly   239 YYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVT 303
             :..:||:..:.:.:.|                    |..|.:|:.|: :|.......:|||.:.
Mosquito   240 -HSPHLIIAIIYLPAFA--------------------LSMLNIFVCLL-DSRVKEKIVIPLICMI 282

  Fly   304 ILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIK 368
            ....|          |.|:|:..|.:.   ..::|::| |::||.::               ::.
Mosquito   283 FHFQL----------LQQMSNPTPEIP---GVVLFIIA-SMILTFLL---------------FVS 318

  Fly   369 SVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKSLLAN-----VLDIDDDFRHTIS 428
            ::..:||        .|.:.|...|::           ||.:::|:|     :|.:|
Mosquito   319 TLINRWL--------HGLQSTPPNIVI-----------RSMRAILSNRLMNWILKVD-------- 356

  Fly   429 GSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMV 493
                                 :.::|  .|...:|              :::..|..||.....:
Mosquito   357 ---------------------YLSVG--QKTCTII--------------NNDERLTLDWVMFVKL 384

  Fly   494 VDRFCL----IVFTLF 505
            ||||.|    |::.||
Mosquito   385 VDRFILAAYVIIYLLF 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	94/533 (18%)
		LGIC_ECD_nAChR	55..236	CDD:349798	37/200 (19%)
		Cys-loop	154..168	CDD:349798	4/13 (31%)
LOC1268935	XP_307512.4	None