Protein Alignment nAChRalpha6 and CHRNE

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_000071.1
• Gene: CHRNE / 1145
• HGNCID: 1966
• Length: 493
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 146/514 - (28%)
• Similarity: 253/514 - (49%)
• Gaps: 76/514 - (14%)

  Fly    14 LLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTT 78
            :|:.|.::........|.||.:||.:.|:...|||....:.:.:...:||..:|.::||.:.|||
Human     8 VLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTT 72

  Fly    79 NAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCL 143
            :.|:.::|.||.|.:::.::||::.||:....:|.|::::.|:.|..|...|..|::|...||..
Human    73 SVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVT 137

  Fly   144 YVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG--------DLSDFITN 200
            ::||.|::|.|.:::|:||||.|:|.:.|.|.||:..:::.....::.|        |...:..|
Human   138 WLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTEN 202

  Fly   201 GEWYLLAMPGKKNTIVYACCPEP-YVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPD 264
            |||.:...||............| ..|:.:::.|||:.|:|..|:||||||||.:.||.:.||..
Human   203 GEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQ 267

  Fly   265 S-GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPL 328
            : |:|.|:.:.:||:.||||.|:|:.:|.||.:|||:|     ...:|:.:||..:
Human   268 AGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLG-----RFLIFVMVVATLI--------- 318

  Fly   329 LGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWIL---------RMGRP 384
               ..||            |:|||...||...|.|.|.::.|.|:.||.:|         |...|
Human   319 ---VMNC------------VIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASP 368

  Fly   385 GRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEH 449
            .|:.:...:||  |.:||.||:..|:.:.       :..||. .|:.|     |:|.:
Human   369 PRRASSVGLLL--RAEELILKKPRSELVF-------EGQRHR-QGTWT-----AAFCQ------- 411

  Fly   450 HTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFC----LIVFTL 504
              ::|....::...:..:.|:....|..:...|.:.||......:|..|    |::|::
Human   412 --SLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSV 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	146/514 (28%)
		LGIC_ECD_nAChR	55..236	CDD:349798	55/189 (29%)
		Cys-loop	154..168	CDD:349798	7/13 (54%)
CHRNE	NP_000071.1	LGIC_ECD_nAChR_E	49..239	CDD:349831	55/189 (29%)
		Cys-loop	148..162	CDD:349831	7/13 (54%)
		Neur_chan_memb	247..474	CDD:460753	76/275 (28%)