Protein Alignment nAChRalpha6 and Chrnd

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_067611.2
• Gene: Chrnd / 11447
• MGIID: 87893
• Length: 520
• Species: Mus musculus
• Alignment Length: 547
• Identity: 167/547 - (30%)
• Similarity: 256/547 - (46%)
• Gaps: 99/547 - (18%)

  Fly     8 SLSLFVLLIFLAI-----IKESCQGPHEKRLLNHLLST--YNTLERPVANESEPLEVKFGLTLQQ 65
            :|.|...|:..|:     :.|      |:||:.||.:.  |:...||||.:.:.::|...|||..
Mouse     7 TLGLLAALVVCALPGSWGLNE------EQRLIQHLFNEKGYDKDLRPVARKEDKVDVALSLTLSN 65

  Fly    66 IIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTY 130
            :|.:.|..:.||||.|::..|.|..|:|:..::|.:..||:.|:.:|.|::::.|:.|..|..:|
Mouse    66 LISLKEVEETLTTNVWIDHAWVDSRLQWDANDFGNITVLRLPPDMVWLPEIVLENNNDGSFQISY 130

  Fly   131 HTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG--- 192
            ..|::|..:|...::||.||:|:|.|.:|:||||.|:|.:||.|..|...::.|.|..|:..
Mouse   131 ACNVLVYDSGYVTWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQEEENNRS 195

  Fly   193 --------DLSDFITNGEWYLLAMPGKKNTIVYACCPEPYV--------DITFTIQIRRRTLYYF 241
                    |...|..||||.::....|.|.       :|.|        |:||.:.|||:.|:|.
Mouse   196 YPIEWIIIDPEGFTENGEWEIVHRAAKLNV-------DPSVPMDSTNHQDVTFYLIIRRKPLFYI 253

  Fly   242 FNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILL 306
            .|::|||||||.|..|.|.||.|.|||.::.:::||:.:|||.|:::.:|.||.|:||:|..:|.
Mouse   254 INILVPCVLISFMINLVFYLPGDCGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLVGKFLLF 318

  Fly   307 SLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVF 371
            .                             |.:|...||:.|:|||.|.||...|.:...:|..|
Mouse   319 G-----------------------------MVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKFF 354

  Fly   372 LQWLPWILRMGRPG------RKITRKTILLSNRMKELE---LKERSSKSLLANVLDIDDDFRHTI 427
            |:.||.:|.|.||.      |.:.|::..|....|..|   ||.||      :::......||.:
Mouse   355 LETLPKLLHMSRPAEEDPGPRALIRRSSSLGYICKAEEYFSLKSRS------DLMFEKQSERHGL 413

  Fly   428 SGSQTAI----GSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWK 488
            :...|..    .||....:....|......|.|            ||...||..:...|...:|.
Mouse   414 ARRLTTARRPPASSEQVQQELFNEMKPAVDGAN------------FIVNHMRDQNSYNEEKDNWN 466

  Fly   489 FAAMVVDRFCLIVFTLFTIIATVTVLL 515
            ..|..|||.||.|.|...::.|..:.|
Mouse   467 QVARTVDRLCLFVVTPVMVVGTAWIFL 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	166/544 (31%)
		LGIC_ECD_nAChR	55..236	CDD:349798	64/199 (32%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
Chrnd	NP_067611.2	LGIC_ECD	29..249	CDD:475126	74/226 (33%)
		Neur_chan_memb	256..492	CDD:460753	83/282 (29%)