Protein Alignment nAChRalpha6 and Chrnb2

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_033732.2
• Gene: Chrnb2 / 11444
• MGIID: 87891
• Length: 501
• Species: Mus musculus
• Alignment Length: 503
• Identity: 191/503 - (37%)
• Similarity: 283/503 - (56%)
• Gaps: 56/503 - (11%)

  Fly    25 CQG----PHEKRLLNHLL--STYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLN 83
            |.|    ..|:||:.|||  |.||.|.||..|.||.:.|:..::|.|:|.|.|:.||:|||.||.
Mouse    20 CSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLT 84

  Fly    84 LEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPG 148
            .||.||.|.|...::..:|.:|:....:|.|||::||:||..::.::::|.||.::||..::||.
Mouse    85 QEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPA 149

  Fly   149 IFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAMPGKKN 213
            |:||.|||::..||||.|:|.|||.|||||..::||||.| |...|.||..:|||.::|:||::|
Mouse   150 IYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKS-DVASLDDFTPSGEWDIIALPGRRN 213

  Fly   214 TIVYACCPE--PYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTIL 276
            .     .|:  .|||||:...|||:.|:|..|||:|||||:|:|:|.|.||.|.|||:||.:::|
Mouse   214 E-----NPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVL 273

  Fly   277 LSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVA 341
            |:|||||.|:::.:|.||..|||:                             |.|....|.:|.
Mouse   274 LALTVFLLLISKIVPPTSLDVPLV-----------------------------GKYLMFTMVLVT 309

  Fly   342 SSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELE--- 403
            .|:|.:|.|||.|||:...|.|.||:|.|||:.||.:|.:.:|..:..|:.:.|..|.:|.|
Mouse   310 FSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQPRHRCARQRLRLRRRQREREGAG 374

  Fly   404 -LKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKEL 467
             |..|...:.......::......::|:..|..::|..||         ::|.....|...:..:
Mouse   375 TLFFREGPAADPCTCFVNPASMQGLAGAFQAEPAAAGLGR---------SMGPCSCGLREAVDGV 430

  Fly   468 QFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515
            :||...||..||:..:..|||:.|||:||..|.:|....:..|:.:.|
Mouse   431 RFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	191/503 (38%)
		LGIC_ECD_nAChR	55..236	CDD:349798	80/182 (44%)
Chrnb2	NP_033732.2	LIC	29..478	CDD:273305	188/492 (38%)
		Neur_chan_LBD	29..234	CDD:280998	96/210 (46%)
		Neur_chan_memb	241..477	CDD:280999	89/273 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910