DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha6 and Chrna7

DIOPT Version :9

Sequence 1:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_031416.3	Gene:	Chrna7 / 11441	MGIID:	99779	Length:	502	Species:	Mus musculus

Alignment Length:	520	Identity:	245/520 - (47%)
Similarity:	321/520 - (61%)	Gaps:	47/520 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTT 78
            |.:..|::..|.||..::||...|:..||.|||||||:|:||.|.|.|:|.||:|||||||:|||
Mouse    10 LALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTT 74

  Fly    79 NAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCL 143
            |.||.:.|.|:.|:||.:||.|||::|....::||||:|:||||||.||.|:|||::|..:|.|.
Mouse    75 NIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQ 139

  Fly   144 YVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYLLAM 208
            |:|||||||:|.||:.|||||.|.|::|||||:|.|..|||.:..   .|:|.:|.||||.|:.:
Mouse   140 YLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQE---ADISSYIPNGEWDLMGI 201

  Fly   209 PGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGV 273
            |||:|...|.||.|||.|:|:|:.:|||||||..||::||||||::|||.|.||.|||||::||:
Mouse   202 PGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGI 266

  Fly   274 TILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMF 338
            |:|||||||:.||||.||.|||:||||                             ..||...|.
Mouse   267 TVLLSLTVFMLLVAEIMPATSDSVPLI-----------------------------AQYFASTMI 302

  Fly   339 MVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELE 403
            :|..|||:||:||.|||...|..:||.|.:.:.|.|..|.|||.|||....|.......|...|.
Mouse   303 IVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLA 367

  Fly   404 LKERSS----KSLLANVLDIDDDFRHTISGSQTA--IGSSASFGR----PTTVEE--HHTAIGCN 456
            ..|.|:    .:...|:|.|  .|| .:.|...|  ..|....||    ||..|.  |.|.....
Mouse   368 SVELSAGAGPPTSNGNLLYI--GFR-GLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGTHPSDG 429

  Fly   457 HKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHII 521
            ..||..||:|:::|..|.|..|:...:..:|||||.||||.||:.|::||||.|:.:|:|||:.:
Mouse   430 DPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFV 494

Fly 522 521
Mouse 495 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	242/514 (47%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	101/180 (56%)
Chrna7	NP_031416.3	LIC	4..490	CDD:273305	242/514 (47%)
		Neur_chan_LBD	26..230	CDD:280998	116/206 (56%)
		Neur_chan_memb	237..486	CDD:280999	114/280 (41%)
		Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane. /evidence=ECO:0000269\|PubMed:32783947	260..267		4/6 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1601
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	490	1.000	Inparanoid score	I1396
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		otm42401
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820