Protein Alignment nAChRalpha6 and CHRND

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_000742.1
• Gene: CHRND / 1144
• HGNCID: 1965
• Length: 517
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 166/509 - (32%)
• Similarity: 249/509 - (48%)
• Gaps: 66/509 - (12%)

  Fly    30 EKRLLNHLLST--YNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLR 92
            |:||:.||...  ||...||||::.|.::|...|||..:|.:.|..:.||||.|:...|.|..|:
Human    25 EERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLK 89

  Fly    93 WNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKID 157
            ||..|:|.:..||:.|:.:|.|::::.|:.|..|..:|..|::|.|.|...::||.||:|:|.|.
Human    90 WNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPIS 154

  Fly   158 ITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG-----------DLSDFITNGEWYLLAMPGK 211
            :|:||||.|:|.:||.|..|...::.|.|..:...           |...|..||||.::..|.:
Human   155 VTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPAR 219

  Fly   212 KNTIVYACCPEP-YVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTI 275
            .|....|....| ..||||.:.|||:.|:|..|::|||||||.|..|.|.||.|||||.::.:::
Human   220 VNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISV 284

  Fly   276 LLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMV 340
            ||:.:|||.|:::.:|.||.|:||||..:|..                             |.:|
Human   285 LLAQSVFLLLISKRLPATSMAIPLIGKFLLFG-----------------------------MVLV 320

  Fly   341 ASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGR-------PGRKITRKTIL--LS 396
            ...||:.|:|||.|.||...|.:...:|.:||:.||.:|.|.|       ||..:.|.:.|  :|
Human   321 TMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGYIS 385

  Fly   397 NRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLH 461
            ...:...||.||      :::......||.::...|.....     |.:.|:....:   ..:|.
Human   386 KAEEYFLLKSRS------DLMFEKQSERHGLARRLTTARRP-----PASSEQAQQEL---FNELK 436

  Fly   462 LILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515
            ..:....||...||..::..|....|...|..|||.||.|.|...::.|..:.|
Human   437 PAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFL 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	166/509 (33%)
		LGIC_ECD_nAChR	55..236	CDD:349798	67/192 (35%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
CHRND	NP_000742.1	LGIC_ECD_nAChR_D	26..246	CDD:349829	79/219 (36%)
		Cys-loop	151..165	CDD:349829	8/13 (62%)
		Neur_chan_memb	253..489	CDD:460753	82/278 (29%)