Protein Alignment nAChRalpha6 and Chrna1

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_031415.2
• Gene: Chrna1 / 11435
• MGIID: 87885
• Length: 457
• Species: Mus musculus
• Alignment Length: 510
• Identity: 187/510 - (36%)
• Similarity: 278/510 - (54%)
• Gaps: 72/510 - (14%)

  Fly     9 LSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKN 73
            ||..:||:.|..........||.||:..|...|:::.|||.:..|.::|..||.|.|:|:|||.|
Mouse     3 LSTVLLLLGLCSAGLVLGSEHETRLVAKLFEDYSSVVRPVEDHREIVQVTVGLQLIQLINVDEVN 67

  Fly    74 QILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKH 138
            ||:|||..|..:|.||||:||..:|||||.:.|...|:|:|||::||:||..|.....|.:::.:
Mouse    68 QIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFAIVKFTKVLLDY 132

  Fly   139 NGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSE-DGGDLSDFITNGE 202
            .|...:.||.||||.|:|.:|.||||:|:|.||.|:|||||:.  :.:|.| |..|||:|:.:||
Mouse   133 TGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSV--VAINPESDQPDLSNFMESGE 195

  Fly   203 WYLLAMPGKKNTIVYACCP-EPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSG 266
            |.:....|.|:.:.|:||| .||:|||:...::|..||:..|:|:||:|.|.:..|.|.||.|||
Mouse   196 WVIKEARGWKHWVFYSCCPTTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLVFYLPTDSG 260

  Fly   267 EKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGT 331
            ||:||.:::||||||||.::.|.:|:||.||||||..:|.:
Mouse   261 EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFT------------------------ 301

  Fly   332 YFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWIL---RMGRPGRKITRKTI 393
                 |..|.:|:::||:|:|.|||:...|.||.|::.||:..:|.|:   .|.||.|
Mouse   302 -----MVFVIASIIITVIVINTHHRSPSTHIMPEWVRKVFIDTIPNIMFFSTMKRPSR------- 354

  Fly   394 LLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHK 458
                        ::..|.:....:||.|     |||..          .|..:..|...|  .|.
Mouse   355 ------------DKQEKRIFTEDIDISD-----ISGKP----------GPPPMGFHSPLI--KHP 390

  Fly   459 DLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTV 513
            ::...::.:::|...|:...:......:||:.|||:|...|.||.|..:|.|:.|
Mouse   391 EVKSAIEGVKYIAETMKSDQESNNAAEEWKYVAMVMDHILLGVFMLVCLIGTLAV 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	185/508 (36%)
		LGIC_ECD_nAChR	55..236	CDD:349798	85/182 (47%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
Chrna1	NP_031415.2	LIC	21..447	CDD:455710	182/492 (37%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	96/210 (46%)
		Cys-loop	148..162	CDD:349815	8/13 (62%)