Protein Alignment nAChRalpha6 and CHRNB4

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_000741.1
• Gene: CHRNB4 / 1143
• HGNCID: 1964
• Length: 498
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 189/528 - (35%)
• Similarity: 285/528 - (53%)
• Gaps: 74/528 - (14%)

  Fly     8 SLSLFVLLIFLAIIKESCQGPH-EKRLLNHLL--STYNTLERPVANESEPLEVKFGLTLQQIIDV 69
            ||.||.|:....  :.:|:..: |::|::.||  :.||.|.||..:.|:.:.:|..|:|.|:|.|
Human     6 SLVLFFLVALCG--RGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISV 68

  Fly    70 DEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNI 134
            :|:.||:|||.||..||.||.|.||.:.|.||..|||...::|.||:::||:||..::.:.:||:
Human    69 NEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNL 133

  Fly   135 VVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFIT 199
            :|:.|||.|::||.|:||.|||::.:||||.|:|.:||.|||||..::|:||.:.. ..:.||..
Human   134 IVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPT-ASMDDFTP 197

  Fly   200 NGEWYLLAMPGKKNTIVYACCPE--PYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLP 262
            :|||.::|:||::..     .|:  .|||:|:...|:|:.|:|..|||:||||.:.:|:|.|.||
Human   198 SGEWDIVALPGRRTV-----NPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLP 257

  Fly   263 PDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIP 327
            .|.|||:||.:::||:||.||.|:::.:|.||..||||
Human   258 SDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLI--------------------------- 295

  Fly   328 LLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKT 392
              |.|....|.:|..|:|.:|.|||.|||:...|.|.||:|..||..||..|.|.|||..
Human   296 --GKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPD----- 353

  Fly   393 ILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTA----- 452
               |:..:...    .|||.:..     .:...|.:......|:|..|..|.:......|
Human   354 ---SSPARAFP----PSKSCVTK-----PEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPV 406

  Fly   453 ----------IGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTI 507
                      .|...:|:...|:.:.||...|:..|::..::.|||:.||||||..|.||....:
Human   407 AIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCV 471

  Fly   508 IATVTVLL 515
            :.||.:.|
Human   472 LGTVGLFL 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	187/525 (36%)
		LGIC_ECD_nAChR	55..236	CDD:349798	79/182 (43%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
CHRNB4	NP_000741.1	LIC	5..480	CDD:455710	189/528 (36%)
		LGIC_ECD	54..231	CDD:475126	79/182 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..377		4/28 (14%)