Protein Alignment nAChRalpha6 and CHRNA7

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001177384.1
• Gene: CHRNA7 / 1139
• HGNCID: 1960
• Length: 531
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 241/531 - (45%)
• Similarity: 318/531 - (59%)
• Gaps: 63/531 - (11%)

  Fly     4 PLPASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIID 68
            |.|..:||              ||..:::|...|:..||.|||||||:|:||.|.|.|:|.||:|
Human    43 PAPGPVSL--------------QGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMD 93

  Fly    69 VDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTN 133
            ||||||:||||.||.:.|.|:.|:||.:||.|||.:|....::||||:|:||||||.||.|:|||
Human    94 VDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTN 158

  Fly   134 IVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFI 198
            ::|..:|.|.|:|||||||:|.||:.|||||.|||::|||||:|.|..|||.:..   .|:|.:|
Human   159 VLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQE---ADISGYI 220

  Fly   199 TNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPP 263
            .||||.|:.:|||::...|.||.|||.|:|||:.:|||||||..||::||||||::|||.|.||.
Human   221 PNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPA 285

  Fly   264 DSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPL 328
            |||||::||:|:|||||||:.||||.||.|||:||||
Human   286 DSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLI---------------------------- 322

  Fly   329 LGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTI 393
             ..||...|.:|..|||:||:||.|||...|..:||.|.:.:.|.|..|.|||.|||....|...
Human   323 -AQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPAC 386

  Fly   394 LLSNRMKELELKERSS----KSLLANVLDIDDDFR-----HTISGSQTAIGSSASFGRPTTVEEH 449
            ....|...|...|.|:    .:...|:|.|  .||     |.:....:.:........||  .:.
Human   387 QHKQRRCSLASVEMSAVAPPPASNGNLLYI--GFRGLDGVHCVPTPDSGVVCGRMACSPT--HDE 447

  Fly   450 HTAIGC----NHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIAT 510
            |...|.    ...||..||:|:::|..|.|..|:...:..:|||||.||||.||:.|::||||.|
Human   448 HLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICT 512

  Fly   511 VTVLLSAPHII 521
            :.:|:|||:.:
Human   513 IGILMSAPNFV 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	235/518 (45%)
		LGIC_ECD_nAChR	55..236	CDD:349798	102/180 (57%)
CHRNA7	NP_001177384.1	LIC	3..519	CDD:273305	238/525 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	282	1.000	Domainoid score	I1660
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1468
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm8451
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820