Protein Alignment nAChRalpha6 and CHRNA3

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_000734.2
• Gene: CHRNA3 / 1136
• HGNCID: 1957
• Length: 505
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 193/518 - (37%)
• Similarity: 290/518 - (55%)
• Gaps: 36/518 - (6%)

  Fly     4 PLPASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIID 68
            ||..|....:||:.|:::..:.....|.||...|...||.:.|||||.|:|:.:.|.:::.|::.
Human     9 PLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVK 73

  Fly    69 VDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTN 133
            |||.|||:.||.||...||||.|:||.::|||.:.:|:...|:||||:::||:|...|.....|.
Human    74 VDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTK 138

  Fly   134 IVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFI 198
            .::|:.|...::||.||||:||||:|:||||.|:|.||||||:||..::||||.. ...:|.|:.
Human   139 ALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIG-SSMNLKDYW 202

  Fly   199 TNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPP 263
            .:|||.::..||.|:.|.|.||.|.|.|||:::.|||..|:|..|||:||:|||.:.:|.|.||.
Human   203 ESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS 267

  Fly   264 DSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPL 328
            |.|||:||.:::||||||||.::.|::|:||..:||||..:|.:
Human   268 DCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFT--------------------- 311

  Fly   329 LGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGR---KITR 390
                    |..|..|:|:||.|||.|:||...|.||.|:|:|||..||.::.|.||..   ...:
Human   312 --------MIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQK 368

  Fly   391 KTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGS-SASFGRPTTVEEHHTAIG 454
            ...|....:..|....|:............|.........:..|.: ||:..|.::.|.....:.
Human   369 PRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLS 433

  Fly   455 CN--HKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515
            .:  ..::...::.:::|...|:..::..|:..|||:.|||:||..|.||||..|:.|..:.|
Human   434 LSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFL 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	190/511 (37%)
		LGIC_ECD_nAChR	55..236	CDD:349798	83/180 (46%)
CHRNA3	NP_000734.2	Neur_chan_LBD	30..496	CDD:332142	186/495 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910