Protein Alignment nAChRalpha6 and Chrna3

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_660111.3
• Gene: Chrna3 / 110834
• MGIID: 87887
• Length: 499
• Species: Mus musculus
• Alignment Length: 518
• Identity: 192/518 - (37%)
• Similarity: 289/518 - (55%)
• Gaps: 42/518 - (8%)

  Fly     6 PASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVD 70
            |..||:.:|::.|..:..:.:..|  ||..:|...||.:.|||||.|.|:.::|.:::.|::.||
Mouse     7 PPPLSMLMLVLMLLPVASASEAEH--RLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQLVKVD 69

  Fly    71 EKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIV 135
            |.|||:.||.||...||||.|:|..::|.||:.:|:...|:||||:::||:||..|.....|..:
Mouse    70 EVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKAL 134

  Fly   136 VKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITN 200
            :|:.|...::||.||||:||||:|:||||.|:|.||||||:||..::||||.. ...:|.|:..:
Mouse   135 LKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIG-SSMNLKDYWES 198

  Fly   201 GEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS 265
            |||.::..||.|:.|.|.||.|.|.|||:::.|||..|:|..|||:||:|||.:.:|.|.||.|.
Mouse   199 GEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDC 263

  Fly   266 GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLG 330
            |||:||.:::||||||||.::.|::|:||..:||||..:|.:
Mouse   264 GEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFT----------------------- 305

  Fly   331 TYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP-----GRKITR 390
                  |..|..|:|:||.|||.|:||...|.||.|:|:|||..||.::.|.||     ....||
Mouse   306 ------MIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSTEEDAPKTR 364

  Fly   391 KTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGS-SASFGRPTTVEEHHTAIG 454
            .  .....:..|....|:............|.........:..|.: ||:..|.::.|.....:.
Mouse   365 N--FYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSESVDAVLS 427

  Fly   455 CN--HKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515
            .:  ..::...::.:::|...|:..:...|:..|||:.|||:||..|.||.|..|:.|..:.|
Mouse   428 LSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFL 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	189/513 (37%)
		LGIC_ECD_nAChR	55..236	CDD:349798	83/180 (46%)
		Cys-loop	154..168	CDD:349798	10/13 (77%)
Chrna3	NP_660111.3	LIC	24..490	CDD:455710	186/499 (37%)
		LGIC_ECD_nAChR_A3	29..235	CDD:349817	97/208 (47%)
		Cys-loop	153..167	CDD:349817	10/13 (77%)