DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha6 and Chrna3

DIOPT Version :9

Sequence 1:NP_995675.1 Gene:nAChRalpha6 / 34304 FlyBaseID:FBgn0032151 Length:523 Species:Drosophila melanogaster
Sequence 2:NP_660111.3 Gene:Chrna3 / 110834 MGIID:87887 Length:499 Species:Mus musculus


Alignment Length:518 Identity:192/518 - (37%)
Similarity:289/518 - (55%) Gaps:42/518 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 PASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVD 70
            |..||:.:|::.|..:..:.:..|  ||..:|...||.:.|||||.|.|:.::|.:::.|::.||
Mouse     7 PPPLSMLMLVLMLLPVASASEAEH--RLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQLVKVD 69

  Fly    71 EKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIV 135
            |.|||:.||.||...||||.|:|..::|.||:.:|:...|:||||:::||:||..|.....|..:
Mouse    70 EVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKAL 134

  Fly   136 VKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITN 200
            :|:.|...::||.||||:||||:|:||||.|:|.||||||:||..::||||.. ...:|.|:..:
Mouse   135 LKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIG-SSMNLKDYWES 198

  Fly   201 GEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS 265
            |||.::..||.|:.|.|.||.|.|.|||:::.|||..|:|..|||:||:|||.:.:|.|.||.|.
Mouse   199 GEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDC 263

  Fly   266 GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLG 330
            |||:||.:::||||||||.::.|::|:||..:||||..:|.:                       
Mouse   264 GEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFT----------------------- 305

  Fly   331 TYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP-----GRKITR 390
                  |..|..|:|:||.|||.|:||...|.||.|:|:|||..||.::.|.||     ....||
Mouse   306 ------MIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSTEEDAPKTR 364

  Fly   391 KTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGS-SASFGRPTTVEEHHTAIG 454
            .  .....:..|....|:............|.........:..|.: ||:..|.::.|.....:.
Mouse   365 N--FYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSESVDAVLS 427

  Fly   455 CN--HKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515
            .:  ..::...::.:::|...|:..:...|:..|||:.|||:||..|.||.|..|:.|..:.|
Mouse   428 LSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFL 490

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha6NP_995675.1 LIC 11..517 CDD:273305 189/513 (37%)
LGIC_ECD_nAChR 55..236 CDD:349798 83/180 (46%)
Chrna3NP_660111.3 LIC 24..490 CDD:273305 186/499 (37%)
LGIC_ECD_nAChR_A3 29..235 CDD:349817 97/208 (47%)
Cys-loop 153..167 CDD:349817 10/13 (77%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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