Protein Alignment nAChRalpha6 and Chrnb3

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_775304.1
• Gene: Chrnb3 / 108043
• MGIID: 106212
• Length: 464
• Species: Mus musculus
• Alignment Length: 522
• Identity: 174/522 - (33%)
• Similarity: 267/522 - (51%)
• Gaps: 89/522 - (17%)

  Fly    14 LLIFLAIIKE--------------SCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQ 64
            |.:|||:...              |....||..||.||...|....|||.|.|:.::|.|||.:.
Mouse     5 LRVFLALSATLSGSWVTLTATAGLSSVAEHEDALLRHLFQGYQKCVRPVLNSSDIIKVYFGLKIS 69

  Fly    65 QIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGT 129
            |::|||||||::|||.||..||.|..||||..:|||:..:::....||.||::::.:||..|:|:
Mouse    70 QLVDVDEKNQLMTTNVWLKQEWTDQKLRWNPEDYGGINSIKVPSESLWLPDIVLFENADGRFEGS 134

  Fly   130 YHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDL 194
            ..|..:||.:|:..:.||..:||:|.:|:|:||||.|:|.||||||||||..:||:|.:|: .|.
Mouse   135 LMTKAIVKSSGTVSWTPPASYKSSCTMDVTFFPFDKQNCSMKFGSWTYDGTMVDLILINEN-VDR 198

  Fly   195 SDFITNGEWYLL---AMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMAL 256
            .||..||||.:|   .|.|.:....|:     |..:|::..:||..|:|...||:||:.:|.:.:
Mouse   199 KDFFDNGEWEILNAKGMKGNRREGFYS-----YPFVTYSFVLRRLPLFYTLFLIIPCLGLSFLTV 258

  Fly   257 LGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQ 321
            |.|.||.|.||||:|..::|:||||||.::.|.:|::|..:||||..:|.
Mouse   259 LVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLF--------------- 308

  Fly   322 VSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTAD-IHEMPPWIKSVFLQWLPWILRMGRPG 385
                          ||..|..|:::||.|:|.|||::. .|.|.||:|.:||:.||..|.|..|
Mouse   309 --------------IMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLEKLPRWLCMKDP- 358

  Fly   386 RKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHH 450
                               ::|.|             |........|..|......:.|...:..
Mouse   359 -------------------RDRFS-------------FPDGTESKGTVRGKFPGKKKQTPTSDGE 391

  Fly   451 TAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515
            ..:..   .|....:.:::|:..::|....::::.||||.|.|:||..|.:|...:::.:|.:.:
Mouse   392 RVLVA---FLEKASESIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLTASVLGSVLIFI 453

  Fly   516 SA 517
            .|
Mouse   454 PA 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	173/520 (33%)
		LGIC_ECD_nAChR	55..236	CDD:349798	80/183 (44%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
Chrnb3	NP_775304.1	LIC	6..455	CDD:455710	172/519 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..387		3/18 (17%)