DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha6 and LOC101882451

DIOPT Version :9

Sequence 1:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_005174278.4	Gene:	LOC101882451 / 101882451	-ID:	-	Length:	545	Species:	Danio rerio

Alignment Length:	538	Identity:	234/538 - (43%)
Similarity:	314/538 - (58%)	Gaps:	72/538 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTT 78
            ||....::..|.||.|::||...|:..||.|||||.|:|..|.|.|..:|.||:|||||||:|||
Zfish    41 LLSAALLLHVSLQGEHQRRLYRDLMKNYNPLERPVYNDSHSLTVHFSFSLMQIMDVDEKNQVLTT 105

  Fly    79 NAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCL 143
            |.||.|.|.||.||||.::|.||..:|...:.:|:||:|:||||||.||.|:|||::|..:|.|.
Zfish   106 NIWLQLYWTDYYLRWNMSDYPGVNTVRFPDSLIWRPDILLYNSADERFDATFHTNVLVNSSGYCQ 170

  Fly   144 YVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDL-VLNSEDGGDLSDFITNGEWYLLA 207
            |:|||||||||.||:.|||||.|.|::|||||||.|..||| ::|:    |::.:|.||||.|:.
Zfish   171 YLPPGIFKSTCYIDVRWFPFDVQRCDLKFGSWTYGGWALDLQMINA----DITGYIANGEWDLVE 231

  Fly   208 MPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLG 272
            :||::|...|.||.|||.|:|||:.:|||||||..||::||||||::|||.|.||.|||||::||
Zfish   232 VPGRRNEKFYDCCKEPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPADSGEKISLG 296

  Fly   273 VTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIM 337
            :|:|||||||:.||||.||.|||:||||                             ..||...|
Zfish   297 ITVLLSLTVFMLLVAEIMPATSDSVPLI-----------------------------AQYFATTM 332

  Fly   338 FMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKEL 402
            .:|..||:.||:||.||:...|..:||.|.:.:.|.|..|.|||.|||.  .|..:...|:.
Zfish   333 VIVGLSVIATVLVLQYHYHDPDGAKMPKWTRVLLLNWCAWFLRMRRPGE--DRIRLACHNKP--- 392

  Fly   403 ELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAI-------------- 453
              ..|||.|.:.  |.:.........|:....|.....|...|..|.|:.:
Zfish   393 --ARRSSVSSVE--LSVSQGALQAAGGNMLYFGFRGMEGVHYTAHESHSVLCSRLMANSEDDVLL 453

  Fly   454 ---------------GCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFT 503
                           |....:|..||:|:::|..|.|..|.:..:..:|||||.|:||.||:.|:
Zfish   454 PGAQIRGGVTSGIVGGTLELELAKILEEVRYIAKRFRDQDADESVCNEWKFAAAVIDRLCLMAFS 518

  Fly   504 LFTIIATVTVLLSAPHII 521
            :|||:.|:.:|:|||:.:
Zfish   519 IFTILCTIGILMSAPNFV 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	231/532 (43%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	102/181 (56%)
LOC101882451	XP_005174278.4	Neur_chan_LBD	55..532	CDD:332142	226/518 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1532
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1280
OMA	1	1.010	-	-		QHG45242
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm6506
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980