Protein Alignment nAChRalpha6 and chrna2

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: XP_004914998.2
• Gene: chrna2 / 100495873
• XenbaseID: XB-GENE-1013893
• Length: 510
• Species: Xenopus tropicalis
• Alignment Length: 548
• Identity: 207/548 - (37%)
• Similarity: 295/548 - (53%)
• Gaps: 79/548 - (14%)

  Fly     1 MDSPLPASLSLFVLLIFLAIIK--ESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTL 63
            |::.:..:||:...:|....:.  |..:...|:||...|.:.||...|||.|.|:.:.|||||::
 Frog     1 MENCMGGTLSILCWMITFTTVSCMERTRTHAEERLFKRLFTGYNRWSRPVPNTSDVVIVKFGLSI 65

  Fly    64 QQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDG 128
            .|:||||||||::|||.||..|||||.||||..:|..|..:|:....:|.||:::||:||..|..
 Frog    66 AQLIDVDEKNQMMTTNVWLKQEWNDYKLRWNPADYDNVTSIRVPSEMIWIPDIVLYNNADGEFAI 130

  Fly   129 TYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGD 193
            |:.|...:.|||...:|||.|:||:|.||:|:||||.|.|:|||||||||...|||. :.|...|
 Frog   131 THMTKAHLFHNGKVKWVPPAIYKSSCSIDVTFFPFDQQSCKMKFGSWTYDKAWLDLE-SMERNVD 194

  Fly   194 LSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLG 258
            |.|:..:|||.::...||.|:..|.||.|.|.|||:...|||..|:|..|||:||:|||.:.:|.
 Frog   195 LKDYWESGEWAIVNAVGKYNSKKYDCCTEIYPDITYYFIIRRLPLFYTINLIIPCLLISCLTVLV 259

  Fly   259 FTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVS 323
            |.||.|.|||:||.:::||||||||.|:.|.:|:||..:||||..:|.:
 Frog   260 FYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFT---------------- 308

  Fly   324 DAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKI 388
                         |..|..|:|:||.|||.|||:...|:||.|::||||..:|..|.|.||...:
 Frog   309 -------------MIFVTLSIVITVFVLNVHHRSPSTHKMPLWVRSVFLDHIPRWLFMKRPPAPV 360

  Fly   389 TRKTILLSNRMKELELKERSSKSLLANVLDIDD----------------------------DFRH 425
            ..    :.::....|||..:||..:..  |:||                            |:.|
 Frog   361 EE----VVSQYDAPELKLSTSKYWMET--DVDDKWAEPEAELQTCHVRHMTTHNQSLQYRYDYNH 419

  Fly   426 TISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKELQ---FITARMRKADDEAELIGDW 487
            .:||.|:.....:|    |...|....:..:      :||.|:   :|...:|..|.:..:..||
 Frog   420 HVSGGQSQTPRHSS----TETAESSFLLSPS------VLKALEGVHYIANHLRAEDADFSVKEDW 474

  Fly   488 KFAAMVVDRFCLIVFTLFTIIATVTVLL 515
            |:.|||:||..|.:|.:..::.||.:.|
 Frog   475 KYVAMVIDRIFLWMFIIVCLLGTVGLFL 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	204/538 (38%)
		LGIC_ECD_nAChR	55..236	CDD:349798	92/180 (51%)
		Cys-loop	154..168	CDD:349798	9/13 (69%)
chrna2	XP_004914998.2	LIC	9..503	CDD:455710	206/540 (38%)
		LGIC_ECD_nAChR_A2	32..238	CDD:349816	104/206 (50%)
		Cys-loop	156..170	CDD:349816	9/13 (69%)