DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha6 and chrna9

DIOPT Version :9

Sequence 1:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_012811629.2	Gene:	chrna9 / 100493319	XenbaseID:	XB-GENE-983401	Length:	494	Species:	Xenopus tropicalis

Alignment Length:	517	Identity:	190/517 - (36%)
Similarity:	289/517 - (55%)	Gaps:	50/517 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQI 75
            :||||....:  ||.:|.:.:.|...|...|:...|||.:..:.|.|...:||.||.||||:|||
Frog    15 VFVLLDLKGV--ESAKGKYAQMLFRDLFEDYSNALRPVEDTDKALNVSLQITLSQIKDVDERNQI 77

  Fly    76 LTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNG 140
            ||...|:.|.|.|..|:|:..||.|:..:||..|.:|:||:::||.||:.|....:||:|::::|
Frog    78 LTAYLWIRLSWYDAYLKWDRDEYDGLDSIRIPSNMVWRPDIVLYNKADDEFSEPVNTNVVLRYDG 142

  Fly   141 SCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGEWYL 205
            ...:..|.|.||:|.:|:::||||:|.|.:.||||||:|||:| ::|:.|.||||||:.|.||.:
Frog   143 KITWDSPAITKSSCVVDVSYFPFDNQQCNLTFGSWTYNGNQVD-IINTMDSGDLSDFVENVEWEM 206

  Fly   206 LAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLT 270
            ..||..||.|.|.||.|||.|||||:.::||:.:|.|||::|||:||.:|.|||.||.|||||::
Frog   207 QGMPAVKNVITYGCCSEPYPDITFTLILKRRSSFYIFNLLIPCVMISFLAPLGFYLPADSGEKVS 271

  Fly   271 LGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNC 335
            ||||:||:||||..:||||||.                              |:::||:|.|:..
Frog   272 LGVTVLLALTVFQLMVAESMPP------------------------------SESVPLIGKYYIA 306

  Fly   336 IMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKIT---RKTILLSN 397
            .|.|:.:|..||::::|.|....:...:|.|.:.|.|.::..|..:...|...|   ..:...||
Frog   307 TMTMITASTALTIIIMNIHLCGPEAKPIPRWARIVILDYMSKIFFVYDVGENCTSPQSDSDTKSN 371

  Fly   398 ----RMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGS-SASFGRPTTVEEHHTAIGCNH 457
                ..::.| ||:...|.|...|....:|...|..::...|. ...:.....:.|.|....||.
Frog   372 GSVPSYEDYE-KEQEPYSSLGCPLSGSGNFSCDIDTNKKLNGHLGGHYALQKEISETHCCAHCNR 435

  Fly   458 KDLHLILKELQFIT--ARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 517
              ..::...:::||  .|.:||.....:  :||..|.|:|||.:.||  |:::..:::|:.|
Frog   436 --YRVLTNNIEYITNWYREQKAISAKGI--EWKKVAKVMDRFFMWVF--FSMVFFMSILIIA 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	189/515 (37%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	88/180 (49%)
chrna9	XP_012811629.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920