Protein Alignment nAChRalpha6 and chrnb3

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: XP_002942943.1
• Gene: chrnb3 / 100379831
• XenbaseID: XB-GENE-5793509
• Length: 460
• Species: Xenopus tropicalis
• Alignment Length: 519
• Identity: 178/519 - (34%)
• Similarity: 275/519 - (52%)
• Gaps: 85/519 - (16%)

  Fly     8 SLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEK 72
            |||:.|..|.....|.......|..||..|.:.|....|||.|.:..::|.|||.:.|::|||||
 Frog     9 SLSITVYFINSGFAKFHPLAEIEDALLRKLFAGYQKWVRPVLNPNSTIKVNFGLKISQLVDVDEK 73

  Fly    73 NQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVK 137
            .|::|||.||..||.|..||||..:|||:..:|:....||.||::::.:||..|:|:..|..::|
 Frog    74 KQLMTTNVWLRQEWMDMKLRWNPKDYGGITYIRVPSESLWLPDIVLFENADGRFEGSLMTKAIIK 138

  Fly   138 HNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGE 202
            ::|:..:.||..:||:|.:|:|:||||.|:|.|||||||||||.:||:|..|: .|..||..|||
 Frog   139 YDGTVTWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGNMVDLILLDEN-VDRKDFFDNGE 202

  Fly   203 WYLL---AMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPD 264
            |.:|   .:.|.:...:|:     |..||::..:||..|:|...||:||:.:|.:.:|.|.||.|
 Frog   203 WDILNATGLKGMRKDGLYS-----YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSD 262

  Fly   265 SGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLL 329
            .||||:|..::|:||||||.::.|.:|::|..:||||..:|.
 Frog   263 EGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLF----------------------- 304

  Fly   330 GTYFNCIMFMVASSVVLTVVVLNYHHR-TADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTI 393
                  ||..|..|:::||.|:|.||| :|..|.|.||:|.:||:.||.:|.|  .|.
 Frog   305 ------IMIFVTLSIIVTVFVINVHHRSSATYHPMAPWVKRLFLEKLPKLLCM--KGH------- 354

  Fly   394 LLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEH-HTAIGCNH 457
                                     :|   |.:...|::.:.|:.|  :|:...:: |.:.|  .
 Frog   355 -------------------------VD---RFSFFDSESDVSSAKS--KPSGKRKNIHASDG--E 387

  Fly   458 KDLHLILKE----LQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 517
            |.|...|::    :::|:..::|.....:::.||||.|.|:||..|.:|...:|..:|.:...|
 Frog   388 KVLIAFLEKAADSIKYISTHVKKEHFIRQVVQDWKFVAQVLDRIFLWLFLSVSITGSVLIFTPA 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	174/514 (34%)
		LGIC_ECD_nAChR	55..236	CDD:349798	80/183 (44%)
chrnb3	XP_002942943.1	LIC	2..451	CDD:273305	177/517 (34%)
		LGIC_ECD_nAChR_B3	56..234	CDD:349827	80/183 (44%)
		Cys-loop	155..169	CDD:349827	8/13 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9936
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000