Protein Alignment nAChRalpha6 and chrna1

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: XP_002934647.1
• Gene: chrna1 / 100145177
• XenbaseID: XB-GENE-977139
• Length: 457
• Species: Xenopus tropicalis
• Alignment Length: 520
• Identity: 185/520 - (35%)
• Similarity: 284/520 - (54%)
• Gaps: 82/520 - (15%)

  Fly     1 MDSPLPASLSLFV--LLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTL 63
            ||..|...:.||:  .|:|        ....|.||:|.|..:||.:.|||....:.:.|..||.|
 Frog     1 MDFSLTRLIFLFIAATLVF--------SSEDESRLINDLFKSYNKVVRPVKAFKDKVVVTLGLQL 57

  Fly    64 QQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDG 128
            .|:|:|||.|||:|||..|..:|.|.:|:||..:|||:|.:||:...:|:||:::||:||..|..
 Frog    58 IQLINVDEVNQIVTTNVRLKQQWEDVHLKWNPEDYGGIKKVRISSGDIWRPDIVLYNNADGDFAI 122

  Fly   129 TYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSE-DGG 192
            ...|.:::.:.|..::.||.||||.|::.:|:||||.|:|.||.|:|||||:.  :|:|.| |..
 Frog   123 VQETKVLLDYTGKIIWTPPAIFKSYCEMIVTYFPFDLQNCSMKLGTWTYDGSL--VVINPESDRP 185

  Fly   193 DLSDFITNGEWYLLAMPGKKNTIVYACCPE-PYVDITFTIQIRRRTLYYFFNLIVPCVLISSMAL 256
            |||:|:.:||||:....|.|:.:.|.|||| ||:|||:...::|..||:..|:::||:|.|.:..
 Frog   186 DLSNFMESGEWYMKDYRGWKHWVYYDCCPETPYLDITYHFLLQRLPLYFIVNVVIPCLLFSFLTG 250

  Fly   257 LGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQ 321
            |.|.||.|||||:||.|::||||.|||.::.|.:|:||.||||||..:|.:
 Frog   251 LVFYLPTDSGEKITLSVSVLLSLVVFLLVIVELIPSTSSAVPLIGKYMLFT-------------- 301

  Fly   322 VSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWIL---RMGR 383
                           |..|.:|:|:||:|:|.|||:...|.||.|:|.:|::.:|.::   .|.|
 Frog   302 ---------------MVFVITSIVITVIVINTHHRSPSTHIMPQWLKKIFIETIPRVMFFSTMKR 351

  Fly   384 PGRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEE 448
            |.                   :::..|.:....:||.|     |||.   :|       |..|:.
 Frog   352 PA-------------------QDQQKKKIFTEDIDISD-----ISGK---LG-------PAAVKY 382

  Fly   449 HHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTV 513
            ....:  .:.|:...::..::|...|:...:..:...:|||.|||:|...|.||.:..||.|:.:
 Frog   383 QSPIL--KNPDVKSAIEGAKYIAETMKSDQESNKASEEWKFVAMVLDHLLLAVFMIVCIIGTLAI 445

  Fly   514  513
             Frog   446  445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	182/510 (36%)
		LGIC_ECD_nAChR	55..236	CDD:349798	83/182 (46%)
		Cys-loop	154..168	CDD:349798	7/13 (54%)
chrna1	XP_002934647.1	LIC	21..447	CDD:455710	178/492 (36%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	94/210 (45%)
		Cys-loop	148..162	CDD:349815	7/13 (54%)