Protein Alignment nAChRalpha6 and chrnb2

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001093684.1
• Gene: chrnb2 / 100101688
• XenbaseID: XB-GENE-854457
• Length: 499
• Species: Xenopus tropicalis
• Alignment Length: 534
• Identity: 202/534 - (37%)
• Similarity: 291/534 - (54%)
• Gaps: 82/534 - (15%)

  Fly     3 SPLPASLSLFVLLIFLAIIKESCQGPH-EKRLLNHLL--STYNTLERPVANESEPLEVKFGLTLQ 64
            :||.|:|.|.:.|:      ..|.|.. |:||:.|||  |.||.|.||..|.||.:.|:..::|.
 Frog     7 APLLAALYLLLGLL------PGCLGTDTEERLVEHLLDPSRYNKLIRPATNGSEQVTVQLMVSLA 65

  Fly    65 QIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGT 129
            |:|.|.|:.||:|||.||..||.||.|.|:..|:..:|.:|:....:|.|||::||:||..::.:
 Frog    66 QLISVHEREQIMTTNVWLTQEWEDYRLTWDPAEFDDMKKVRLPSKHIWLPDVVLYNNADGMYEVS 130

  Fly   130 YHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDL 194
            :::|.||.|:||..::||.|:||.|||::..||||.|:|.|||.|||||..:|||||.| |...|
 Frog   131 FYSNAVVSHDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTELDLVLRS-DVASL 194

  Fly   195 SDFITNGEWYLLAMPGKKNTIVYACCPEP----YVDITFTIQIRRRTLYYFFNLIVPCVLISSMA 255
            .||..:|||.::|:||::|       ..|    |||||:...|||:.|:|..|||:||:||:|:|
 Frog   195 DDFTPSGEWDIIALPGRRN-------ENPNDSTYVDITYDFIIRRKPLFYTINLIIPCILITSLA 252

  Fly   256 LLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLP 320
            :|.|.||.|.|||:||.:::||:|||||.|:::.:|.||..|||:
 Frog   253 ILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLV-------------------- 297

  Fly   321 QVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPG 385
                     |.|....|.:|..|:|.:|.|||.|||:...|.||||:|.|||..||.:|.|.:|.
 Frog   298 ---------GKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMPPWVKVVFLDKLPTLLFMKQPR 353

  Fly   386 RKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGR-------- 442
            :...|:      |:::    :|.|:...|....:.|..|     |.|...:.||..:
 Frog   354 QNCARQ------RLRQ----QRQSQERAAGSFFLRDGAR-----SCTCYVNQASVKKYGAQLSEL 403

  Fly   443 PTTVEEHHTAIG------CNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIV 501
            |..|.......|      |.   |...:..::||...|:..||:..:..|||:.|||:||..|.:
 Frog   404 PEGVNGFRDRQGKVRQCLCG---LQEAVDGVRFIADHMKSEDDDQSVSEDWKYVAMVIDRLFLWI 465

  Fly   502 FTLFTIIATVTVLL 515
            |....:..|:.:.|
 Frog   466 FVFVCVFGTIGMFL 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	198/526 (38%)
		LGIC_ECD_nAChR	55..236	CDD:349798	83/184 (45%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)
chrnb2	NP_001093684.1	LIC	29..479	CDD:455710	193/504 (38%)
		LGIC_ECD_nAChR_B2	31..234	CDD:349826	98/210 (47%)
		Cys-loop	155..169	CDD:349826	8/13 (62%)