Protein Alignment nAChRalpha6 and chrnb1

DIOPT Version :10

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001240739.1
• Gene: chrnb1 / 100006941
• ZFINID: ZDB-GENE-070821-4
• Length: 492
• Species: Danio rerio
• Alignment Length: 510
• Identity: 161/510 - (31%)
• Similarity: 263/510 - (51%)
• Gaps: 76/510 - (14%)

  Fly    30 EKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWN 94
            |.:|:..|.|.||:..||..|..|.:.|:.|:.|...:.::.|::.:.|...:|||||||.|.||
Zfish    26 EDKLMKKLFSAYNSKVRPARNPEERVVVRIGMILSSFVSLNMKDEEMNTIVMMNLEWNDYRLSWN 90

  Fly    95 ETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDIT 159
            ..:||||..|||:..|:|.||:::.|:.|..|......::....||...:.||.::||:|.:.:|
Zfish    91 PKDYGGVDVLRISSGKVWLPDIVLINNNDGVFGVALQVHVQAYSNGRVTWTPPALYKSSCGVKVT 155

  Fly   160 WFPFDDQHCEMKFGSWTYDGNQLDL--VLNSEDGGDLSD------FITNGEWYLLAMPGKKNTIV 216
            :||||.|:|.|.|.|:|||.:::||  .|:.. |.::.:      |..:|||::.....:||.
Zfish   156 YFPFDWQNCTMVFRSYTYDSSEVDLQHALDKR-GKEIKEIILDTGFSESGEWHIRHKVSRKNV-- 217

  Fly   217 YACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTV 281
               ..:.|.||||.:.|.|:.::|..|:::||:||:.:|:..|.||||:|||:.|.:.:||:|||
Zfish   218 ---REDLYEDITFYLIIERKPMFYVVNIVLPCILITIIAIFNFYLPPDAGEKMGLSINVLLTLTV 279

  Fly   282 FLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVL 346
            ||.|:|..:|.||     :||                        |::..|....|.:|..||:|
Zfish   280 FLLLLANKIPETS-----LGV------------------------PIIVNYLMITMILVTFSVIL 315

  Fly   347 TVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP--------GRKITRKTILLSNRM-KEL 402
            :|||||.|||:.:.|:||.|::.:|:..||..|.|.||        .:...::.|...||: .|.
Zfish   316 SVVVLNLHHRSPNTHQMPLWVRKIFIHMLPPYLGMLRPKVETPLFLEKPAKKENIQAINRVADEY 380

  Fly   403 ELKERSSKSLLANVLDIDDDFRHTISGSQTAI-----GSSASFGRPTTVEEHHTAIGCNHKDLHL 462
            .:::.|:.:.|     .....|:...|..|.:     |.|           |:..:   ..:|..
Zfish   381 FIRKPSNMNFL-----FPKPHRYQPDGQCTDLRKFIDGPS-----------HYLTL---PPELKT 426

  Fly   463 ILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 517
            .::.:.:|..:::...|...|..||::.|||.||..|.:|.:||.:.|:.:...|
Zfish   427 AVEAITYIAEQLQAEKDYEALKEDWQYVAMVADRLFLWIFVIFTTLGTLGIFTDA 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	160/508 (31%)
		LGIC_ECD_nAChR	55..236	CDD:349798	65/188 (35%)
		Cys-loop	154..168	CDD:349798	7/13 (54%)
chrnb1	NP_001240739.1	LGIC_ECD	26..235	CDD:475126	76/214 (36%)
		Neur_chan_memb	242..478	CDD:460753	82/283 (29%)