Protein Alignment nAChRalpha6 and chrnb1

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001240739.1
• Gene: chrnb1 / 100006941
• ZFINID: ZDB-GENE-070821-4
• Length: 492
• Species: Danio rerio
• Alignment Length: 510
• Identity: 161/510 - (31%)
• Similarity: 263/510 - (51%)
• Gaps: 76/510 - (14%)

  Fly    30 EKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWN 94
            |.:|:..|.|.||:..||..|..|.:.|:.|:.|...:.::.|::.:.|...:|||||||.|.||
Zfish    26 EDKLMKKLFSAYNSKVRPARNPEERVVVRIGMILSSFVSLNMKDEEMNTIVMMNLEWNDYRLSWN 90

  Fly    95 ETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDIT 159
            ..:||||..|||:..|:|.||:::.|:.|..|......::....||...:.||.::||:|.:.:|
Zfish    91 PKDYGGVDVLRISSGKVWLPDIVLINNNDGVFGVALQVHVQAYSNGRVTWTPPALYKSSCGVKVT 155

  Fly   160 WFPFDDQHCEMKFGSWTYDGNQLDL--VLNSEDGGDLSD------FITNGEWYLLAMPGKKNTIV 216
            :||||.|:|.|.|.|:|||.:::||  .|:.. |.::.:      |..:|||::.....:||.
Zfish   156 YFPFDWQNCTMVFRSYTYDSSEVDLQHALDKR-GKEIKEIILDTGFSESGEWHIRHKVSRKNV-- 217

  Fly   217 YACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTV 281
               ..:.|.||||.:.|.|:.::|..|:::||:||:.:|:..|.||||:|||:.|.:.:||:|||
Zfish   218 ---REDLYEDITFYLIIERKPMFYVVNIVLPCILITIIAIFNFYLPPDAGEKMGLSINVLLTLTV 279

  Fly   282 FLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVL 346
            ||.|:|..:|.||     :||                        |::..|....|.:|..||:|
Zfish   280 FLLLLANKIPETS-----LGV------------------------PIIVNYLMITMILVTFSVIL 315

  Fly   347 TVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP--------GRKITRKTILLSNRM-KEL 402
            :|||||.|||:.:.|:||.|::.:|:..||..|.|.||        .:...::.|...||: .|.
Zfish   316 SVVVLNLHHRSPNTHQMPLWVRKIFIHMLPPYLGMLRPKVETPLFLEKPAKKENIQAINRVADEY 380

  Fly   403 ELKERSSKSLLANVLDIDDDFRHTISGSQTAI-----GSSASFGRPTTVEEHHTAIGCNHKDLHL 462
            .:::.|:.:.|     .....|:...|..|.:     |.|           |:..:   ..:|..
Zfish   381 FIRKPSNMNFL-----FPKPHRYQPDGQCTDLRKFIDGPS-----------HYLTL---PPELKT 426

  Fly   463 ILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 517
            .::.:.:|..:::...|...|..||::.|||.||..|.:|.:||.:.|:.:...|
Zfish   427 AVEAITYIAEQLQAEKDYEALKEDWQYVAMVADRLFLWIFVIFTTLGTLGIFTDA 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	160/508 (31%)
		LGIC_ECD_nAChR	55..236	CDD:349798	65/188 (35%)
chrnb1	NP_001240739.1	LIC	6..479	CDD:273305	160/506 (32%)
		Neur_chan_LBD	26..235	CDD:280998	76/214 (36%)
		Neur_chan_memb	242..478	CDD:280999	82/283 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910