Protein Alignment nAChRalpha6 and chrnb1l

DIOPT Version :9

• Sequence 1: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001233249.1
• Gene: chrnb1l / 100005295
• ZFINID: ZDB-GENE-060811-1
• Length: 486
• Species: Danio rerio
• Alignment Length: 505
• Identity: 172/505 - (34%)
• Similarity: 271/505 - (53%)
• Gaps: 66/505 - (13%)

  Fly    30 EKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWN 94
            |:|||..|...||...||....:|.:.|:.|:||.|:|.:::||..:|||.::|:||.||.|.||
Zfish    20 ERRLLEDLFQDYNLKVRPARTWNERVMVRVGMTLVQLISLNQKNGEMTTNVFMNMEWTDYRLSWN 84

  Fly    95 ETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDIT 159
            ..:|..:..:||.|.|:|:||:.:.|:.|..||...:.|::|:.:|:..::||.|::|:|.|::.
Zfish    85 PEDYDKIDVVRIPPVKVWRPDIYLINNNDGQFDVALYVNVLVRSDGTVSWLPPAIYRSSCSIEVA 149

  Fly   160 WFPFDDQHCEMKFGSWTYDGNQLDLVLN-SEDGGDLSD-------FITNGEWYLLAMPGKKNTIV 216
            :||||.|:|.|.|.|:|||.:::||... .|||.:|.:       |..||||.:...|.:||.
Zfish   150 YFPFDWQNCSMVFRSYTYDSSEVDLQYGLDEDGNELHEIVIDENAFTENGEWQICHKPSRKNV-- 212

  Fly   217 YACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTV 281
               ..:.|.||||.:.|.|:.|:|..|:||||:|.|.:|:..|.|||.:|||:||.:::|::|||
Zfish   213 ---QDDLYEDITFYLIIERKPLFYVINIIVPCILTSVLAIFVFYLPPGAGEKMTLSISVLIALTV 274

  Fly   282 FLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVL 346
            |:.|:|:.:|.||.|:|:|           :|.|..|                  |.:|..||:|
Zfish   275 FMLLLADKVPETSLAIPII-----------VNYVMFT------------------MILVTFSVIL 310

  Fly   347 TVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILLSNRMKELELKERSSKS 411
            :|||||.||||...|.||.|::.||:..||..|.:.||          ......|.|.||.....
Zfish   311 SVVVLNLHHRTPSTHHMPGWVRKVFINLLPRYLGVLRP----------TPEEPVEEEPKENVPMG 365

  Fly   412 LLANVL---------DIDDDFRHTISGSQTAIGSSASFGRPTTVEEHHTAIGCNHKDLHLILKEL 467
            .|.|.|         .|:.:......||...  |:....|.:..:.:...:..|.|.   .:..:
Zfish   366 CLGNSLRPGGEYFIRKINPELVMPWRGSHNE--STVKLQRFSNSDNYCLILPPNLKS---AIAAI 425

  Fly   468 QFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 517
            .:::.:::|.|.:..:..||::.|:|:||..|.:|.:.|.:.|:|:.|.|
Zfish   426 TYMSEQLKKQDVDDTMTDDWQYIAVVLDRLFLWLFVVITTLGTLTMFLDA 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	171/503 (34%)
		LGIC_ECD_nAChR	55..236	CDD:349798	72/188 (38%)
chrnb1l	NP_001233249.1	LIC	11..473	CDD:273305	170/501 (34%)
		Neur_chan_LBD	20..230	CDD:280998	83/214 (39%)
		Neur_chan_memb	237..472	CDD:280999	84/278 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910