Protein Alignment CG13123 and PRDM16

DIOPT Version :10

• Sequence 1: NP_609315.1
• Gene: CG13123 / 34303
• FlyBaseID: FBgn0032150
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_071397.3
• Gene: PRDM16 / 63976
• HGNCID: 14000
• Length: 1276
• Species: Homo sapiens
• Alignment Length: 188
• Identity: 47/188 - (25%)
• Similarity: 77/188 - (40%)
• Gaps: 22/188 - (11%)

  Fly   121 PLDYVVLDP---DRPTETRQTRRR-TDSCTKPSQRLANQDSLIVSEFLPATTAQPRLDLSDSQLE 181
            ||.|....|   | |..:|..:|: ||......::......|:.         .|::...::..|
Human   852 PLHYAKPSPFFMD-PIYSRVEKRKVTDPVGALKEKYLRPSPLLF---------HPQMSAIETMTE 906

  Fly   182 QLESPAYEMRTVDYAAVELKHYNLDEYNEANRLLDVEPSGSQAIYKCQYC----PLAYASPQYLK 242
            :|||.|........:...|.|:..:..:....|.|......:..|.|:||    |.:....::|:
Human   907 KLESFAAMKADSGSSLQPLPHHPFNFRSPPPTLSDPILRKGKERYTCRYCGKIFPRSANLTRHLR 971

  Fly   243 THV-RNSHVCKYCTTAFAKVRDLNEHIRQKHPHH---QCVVCSNNFSTSSNLRAHLKK 296
            ||. ...:.||||..:|:...:|..|:|..|...   :|.:|:..|...:||..||||
Human   972 THTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKK 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13123	NP_609315.1	zf-AD	6..82	CDD:471776
		PHA00733	175..272	CDD:177301	25/101 (25%)
		C2H2 Zn finger	228..245	CDD:275368	6/20 (30%)
		C2H2 Zn finger	251..272	CDD:275368	8/20 (40%)
		KREPA	<269..>303	CDD:483960	11/31 (35%)
		C2H2 Zn finger	277..298	CDD:275368	9/20 (45%)
PRDM16	NP_071397.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68
		PR-SET_PRDM16	61..222	CDD:380990
		zf-C2H2	281..303	CDD:395048
		C2H2 Zn finger	283..303	CDD:275368
		zf-H2C2_2	295..319	CDD:463886
		zf-C2H2	309..331	CDD:395048
		C2H2 Zn finger	311..331	CDD:275368
		COG5048	<335..492	CDD:227381
		C2H2 Zn finger	339..357	CDD:275368
		C2H2 Zn finger	368..388	CDD:275368
		zf-C2H2	394..416	CDD:395048
		C2H2 Zn finger	396..416	CDD:275368
		C2H2 Zn finger	425..443	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	533..657
		Interaction with CTBP1, CTBP2 and ZNF516. /evidence=ECO:0000250|UniProtKB:A2A935	679..1038		47/188 (25%)
		Mediates interaction with SKI and regulation of TGF-beta signaling. /evidence=ECO:0000269|PubMed:19049980	739..1276		47/188 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	772..804
		COG5048	931..>1083	CDD:227381	28/99 (28%)
		zf-C2H2	951..973	CDD:395048	6/21 (29%)
		C2H2 Zn finger	953..973	CDD:275368	5/19 (26%)
		zf-H2C2_2	965..989	CDD:463886	7/23 (30%)
		C2H2 Zn finger	981..1002	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1010..1030	CDD:275368	9/20 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1033..1065
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1105..1163