DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4036 and ALKBH4

DIOPT Version :9

Sequence 1:	NP_001188762.1	Gene:	CG4036 / 34302	FlyBaseID:	FBgn0032149	Length:	304	Species:	Drosophila melanogaster
Sequence 2:	NP_060091.1	Gene:	ALKBH4 / 54784	HGNCID:	21900	Length:	302	Species:	Homo sapiens

Alignment Length:	292	Identity:	109/292 - (37%)
Similarity:	164/292 - (56%)	Gaps:	46/292 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IRPCGCKGVRTCLSCEQ--------DFHIAKTSLREQFQQLEAWSYCIQCDLLQRGWDTNHVQKD 60
            :|.|||||:||||.||:        :...|||         ..:.||     ...||.....:.|
Human    12 LRECGCKGIRTCLICERQRGSDPPWELPPAKT---------YRFIYC-----SDTGWAVGTEESD 62

  Fly    61 HENHKKDEGLPLPGILVQEEFLSVDEGAQLIADLDDLPWDISQSGRRKQNFGPKTNFKKRKLRLG 125
            .|..    ..|.||:::.|:|::.:|.|:|:..:|..||.:||||||||::|||.||:|:||:..
Human    63 FEGW----AFPFPGVMLIEDFVTREEEAELVRLMDRDPWKLSQSGRRKQDYGPKVNFRKQKLKTE 123

  Fly   126 SFAGFPRTTEYVQRRFEDVPLLRGFQTIEQCSLEYEPSKGASIDPHVDDCWIWGERVVTVNCLGD 190
            .|.|.|..:..|.||....|.|.||:.:|||:|:|.|.:|::||||:||.|:||||:|::|.|..
Human   124 GFCGLPSFSREVVRRMGLYPGLEGFRPVEQCNLDYCPERGSAIDPHLDDAWLWGERLVSLNLLSP 188

  Fly   191 SVLTLTPYEVQQSGKYNLDLVAS-----YEDELLAP----LLTDDQLATFEGKVLRIPMPNLSLI 246
            :||::..   :..|...|....|     ..|.::||    |..:.::|        ||:|..||:
Human   189 TVLSMCR---EAPGSLLLCSAPSAAPEALVDSVIAPSRSVLCQEVEVA--------IPLPARSLL 242

  Fly   247 VLYGPARYQFEHSVLREDVQERRVCVAYREFT 278
            ||.|.||:|::|::.|..::.|||||.:||.:
Human   243 VLTGAARHQWKHAIHRRHIEARRVCVTFRELS 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4036	NP_001188762.1	2OG-FeII_Oxy	73..>190	CDD:194067	57/116 (49%)
ALKBH4	NP_060091.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160325
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9747
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3851
Isobase	1	0.950	-	0	Normalized mean entropy	S4846
OMA	1	1.010	-	-		QHG51912
OrthoDB	1	1.010	-	-		D515410at33208
OrthoFinder	1	1.000	-	-		FOG0007439
OrthoInspector	1	1.000	-	-		oto88974
orthoMCL	1	0.900	-	-		OOG6_106336
Panther	1	1.100	-	-	LDO	PTHR12463
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4092
SonicParanoid	1	1.000	-	-		X5571
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.890