DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IP3K1 and Itpka

DIOPT Version :9

Sequence 1:	NP_609313.2	Gene:	IP3K1 / 34300	FlyBaseID:	FBgn0032147	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_112307.2	Gene:	Itpka / 81677	RGDID:	619950	Length:	459	Species:	Rattus norvegicus

Alignment Length:	378	Identity:	140/378 - (37%)
Similarity:	190/378 - (50%)	Gaps:	60/378 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LDTSASSKQRSAMMLEVEQQQQQQQQQQSNNNNERIPNENCDYLSLQRSGQAPKNHIQAQDPAQM 124
            |.||:.|...|:.:||..:.......:..:..|.::...       :..||  |:|.|
  Rat   118 LSTSSLSSTGSSSLLEDSEDDLLSDSESRSRGNVQLETS-------EDVGQ--KSHWQ------- 166

  Fly   125 SLLKFLAINALELSAPATPHLLQHQQAHKQAKPQGWMQLSGHPESIVPTST-GIVRKRISGLEDS 188
               |...:..|.:.:|.             .|...|:||:||..|.....| |::.||     .|
  Rat   167 ---KIRTMVNLPVMSPF-------------KKRYSWVQLAGHTGSFKAAGTSGLILKR-----SS 210

  Fly   189 EVHAYRLI---------CKEPQTAQIVPAYFGIQEMQSQHFIELQDLLAGFRDPCVMDIKMGSRT 244
            |...|.|:         |        |||:.|:.|...:.:::|||||.||..|||:|.|||.||
  Rat   211 EPEHYCLVRLMADVLRGC--------VPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRT 267

  Fly   245 FLESEVSNATLRP----DLYQKMIAVDAGAPTPAEHEARAITKLRYMTFRESLSSSHSKGFRIEA 305
            :||.|::.|..||    |:|:||:|||..|||..||..||:||.|||.:||.:|||.:.|||||.
  Rat   268 YLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEG 332

  Fly   306 LRLRGRPPVKDLKTCRSSEQIAQTIEQFLAARRSVQKELLKRLKHMRLVIEQSTFFASHEIIGSS 370
            ::........|.||.||.||:.:..|:|:.....|.|..|.||:.:|..:|.|.||..||:||||
  Rat   333 IKKADGSCSTDFKTTRSREQVTRVFEEFMQGDAEVLKRYLNRLQQIRDTLEISDFFRRHEVIGSS 397

  Fly   371 IFIVYDD-DRVGVWLIDFAKCRELPPHVRVDHRSAWAPGNREEGLLRGMDELI 422
            :..|:|. .|.|||||||.|...||....:|||..|..||||:|.|.|:|.||
  Rat   398 LLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLI 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IP3K1	NP_609313.2	IPK	220..426	CDD:281727	103/208 (50%)
Itpka	NP_112307.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..164		11/54 (20%)
		IPK	243..453	CDD:397715	103/208 (50%)
		Calmodulin-binding	285..293		4/7 (57%)
		Substrate binding. /evidence=ECO:0000250	310..317		4/6 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344861
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D410791at33208
OrthoFinder	1	1.000	-	-		FOG0001484
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103318
Panther	1	1.100	-	-	O	PTHR12400
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750