DRSC/TRiP Functional Genomics Resources

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Protein Alignment IP3K1 and ITPKC

DIOPT Version :9

Sequence 1:NP_609313.2 Gene:IP3K1 / 34300 FlyBaseID:FBgn0032147 Length:441 Species:Drosophila melanogaster
Sequence 2:NP_079470.1 Gene:ITPKC / 80271 HGNCID:14897 Length:683 Species:Homo sapiens


Alignment Length:499 Identity:140/499 - (28%)
Similarity:219/499 - (43%) Gaps:105/499 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 TSTVLQRPIQAKPEKKASSKS------TSSSRSRSTM--AWSNEKLRFSCIDNIGLKQLWKLIAL 60
            :|::...|..|.|.|:.|:..      |..||::..:  .|:.     ...|....||       
Human   201 SSSLQTHPEGACPSKEPSADGSWKELYTDGSRTQQDIEGPWTE-----PYTDGSQKKQ------- 253

  Fly    61 DTSASSKQRSAMMLEVEQQQQQQQQQQSNNNNERIPNENCDYLSLQRSGQAPKNHIQAQDPAQM- 124
            ||.|:.||......:::|.......|.|.:.::..|..:|      ..|:.....::..:|.:: 
Human   254 DTEAARKQPGTGGFQIQQDTDGSWTQPSTDGSQTAPGTDC------LLGEPEDGPLEEPEPGELL 312

  Fly   125 -SLLKFLAINALELSAPATPHLLQHQQAHKQAKPQG----------------------------- 159
             .|...|..:.|   .|....::..:....:|:|.|                             
Human   313 THLYSHLKCSPL---CPVPRLIITPETPEPEAQPVGPPSRVEGGSGGFSSASSFDESEDDVVAGG 374

  Fly   160 ------------------------------------WMQLSGHPESIVPTSTGIVRKRISGLEDS 188
                                                |:|||||..:......|.:.||....|..
Human   375 GGASDPEDRSGSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQR 439

  Fly   189 EVHAYRLICKEPQTAQIVPAYFGIQEMQSQHFIELQDLLAGFRDPCVMDIKMGSRTFLESEVSNA 253
            .:..   :.|:| ....||||:|:.....|.|.:::||||.|..|.:||.||||||:||.|:..|
Human   440 SLEQ---LMKDP-LRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKA 500

  Fly   254 TLRP----DLYQKMIAVDAGAPTPAEHEARAITKLRYMTFRESLSSSHSKGFRIEALRLRGRPPV 314
            ..||    |:|:||:|||.|||||.||...|:||.|||.:||::||:.:.|||||.::.......
Human   501 RERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADGTCN 565

  Fly   315 KDLKTCRSSEQIAQTIEQFLAARRSVQKELLKRLKHMRLVIEQSTFFASHEIIGSSIFIVYDDDR 379
            .:.|..::.||:.:.:|.|:.....:.::.:..|:.:|..:|.|.||.:||::|||:..|:|...
Human   566 TNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTG 630

  Fly   380 VG-VWLIDFAKCRELPPHVRVDHRSAWAPGNREEGLLRGMDELI 422
            :. ||:|||.|...||.|..:.||..||.||||:|.|.|:|.:|
Human   631 LAKVWMIDFGKTVALPDHQTLSHRLPWAEGNREDGYLWGLDNMI 674

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IP3K1NP_609313.2 IPK 220..426 CDD:281727 90/208 (43%)
ITPKCNP_079470.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..124
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 147..308 24/124 (19%)
Nuclear export signal. /evidence=ECO:0000250 324..332 2/10 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 334..387 3/52 (6%)
IPK 467..678 CDD:281727 90/208 (43%)
Substrate binding 507..513 2/5 (40%)
Calmodulin-binding. /evidence=ECO:0000250 509..517 4/7 (57%)
Substrate binding 534..541 4/6 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1621
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 215 1.000 Inparanoid score I3621
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D410791at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_103318
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1215
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.770

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