DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IP3K1 and IP6K2

DIOPT Version :9

Sequence 1:	NP_609313.2	Gene:	IP3K1 / 34300	FlyBaseID:	FBgn0032147	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	XP_006713262.1	Gene:	IP6K2 / 51447	HGNCID:	17313	Length:	485	Species:	Homo sapiens

Alignment Length:	414	Identity:	84/414 - (20%)
Similarity:	142/414 - (34%)	Gaps:	162/414 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 IPNENCDYLS-LQRSGQAPKNHIQAQDPAQMSLLKFLAINALELSAPATPH--LLQHQ-----QA 151
            :.|.:|:..| |.|.....|:|:                    |....||.  :.||:     ::
Human   158 VDNSDCEPKSKLLRWTTNKKHHV--------------------LETEKTPKDWVRQHRKEEKMKS 202

  Fly   152 HKQAKPQGWMQLSGHPESIVPTSTGIVRKRISGLEDSEVHAYR---LICKEPQTAQIVPAYFGIQ 213
            ||..:...|::.|   |.:..|    |.|:  |...|::..|.   :.|.:.|          :|
Human   203 HKLEEEFEWLKKS---EVLYYT----VEKK--GNISSQLKHYNPWSMKCHQQQ----------LQ 248

  Fly   214 EMQ--SQH-----FIELQDLLAGFRDPCVMDIKMGSRTFLESEVSNATLRPDLYQKMIAVDAGAP 271
            .|:  ::|     ||.|::|.:.:..|||:|:|||:|                       ..|..
Human   249 RMKENAKHRNQYKFILLENLTSRYEVPCVLDLKMGTR-----------------------QHGDD 290

  Fly   272 TPAEHEARAITKLRYMTFRESLSSSHSKGFRIEALRL--------------RGRPPVKDLKTCRS 322
            ...|..|..|.|.:.       |:|...|.|:..:::              .||.        .|
Human   291 ASEEKAANQIRKCQQ-------STSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRK--------LS 340

  Fly   323 SEQIAQTIEQFLAARRSVQKEL----LKRLKHMRLVIEQSTFFASHEIIGSSIFIVYD------- 376
            .:...:.:.||....|.:::||    ||:|..::.|:|:.   .|:....||:.::||
Human   341 VQGFKEALFQFFHNGRYLRRELLGPVLKKLTELKAVLERQ---ESYRFYSSSLLVIYDGKERPEV 402

  Fly   377 -----------------DDRVGVW-------------LIDFA--KCRELPPHVRVDHRSAWAPGN 409
                             |:..|.:             :||||  .|| |.....|.|.      .
Human   403 VLDSDAEDLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCR-LYGEDTVVHE------G 460

  Fly   410 REEGLLRGMDELIRSFEEVYARCG 433
            ::.|.:.|:..||....|:....|
Human   461 QDAGYIFGLQSLIDIVTEISEESG 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IP3K1	NP_609313.2	IPK	220..426	CDD:281727	54/262 (21%)
IP6K2	XP_006713262.1	IPK	262..477	CDD:281727	54/262 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151383
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840