DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IP3K1 and ITPKB

DIOPT Version :9

Sequence 1:	NP_609313.2	Gene:	IP3K1 / 34300	FlyBaseID:	FBgn0032147	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_002212.3	Gene:	ITPKB / 3707	HGNCID:	6179	Length:	946	Species:	Homo sapiens

Alignment Length:	428	Identity:	128/428 - (29%)
Similarity:	189/428 - (44%)	Gaps:	97/428 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PEKKASSKSTSSSRSRSTMAWSNEKLRFSCIDNIGLKQLWKLIALDTSASSKQRSAMMLEVEQQQ 80
            |.:|.||.|.||:...|:...|.|.                 |:.|...:....||.:..::||:
Human   594 PLRKLSSSSASSTGFSSSYEDSEED-----------------ISSDPERTLDPNSAFLHTLDQQK 641

  Fly    81 QQQQQQQSNNNNERIPNENCDYLSLQRSGQAPKNHIQAQDPAQMSLLKFLAINALELSAPATPHL 145
            .:                      :.:|.:..||.:. ..|..||.
Human   642 PR----------------------VSKSWRKIKNMVH-WSPFVMSF------------------- 664

  Fly   146 LQHQQAHKQAKPQGWMQLSGHPESIVPTSTGIVRKRISGLEDSEVHAYRLICKEPQTA------- 203
                   |:..|  |:||:||..|....:.|.:.|:         |     |:..|..
Human   665 -------KKKYP--WIQLAGHAGSFKAAANGRILKK---------H-----CESEQRCLDRLMVD 706

  Fly   204 ---QIVPAYFGIQEMQSQHFIELQDLLAGFRDPCVMDIKMGSRTFLESEVSNA----TLRPDLYQ 261
               ..||||.|......:.:.::.||||.|..|||||.|||.||:||.|::.|    :||.|:||
Human   707 VLRPFVPAYHGDVVKDGERYNQMDDLLADFDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQ 771

  Fly   262 KMIAVDAGAPTPAEHEARAITKLRYMTFRESLSSSHSKGFRIEALRLRGRPPVKDLKTCRSSEQI 326
            |||.||..|||..|...||:||.|||.:||::||:.:.|||||.::.......:|.|..::.||:
Human   772 KMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFRIEGIKKEDGTVNRDFKKTKTREQV 836

  Fly   327 AQTIEQFLAARRSVQKELLKRLKHMRLVIEQSTFFASHEIIGSSIFIVYD-DDRVGVWLIDFAKC 390
            .:...:|.....::......|||.:|..:|.|.||..||:||||:..::| .::..||:|||.|.
Human   837 TEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKT 901

  Fly   391 RELPPHVRVDHRSAWAPGNREEGLLRGMDELIRSFEEV 428
            ..||....:.|...|..||||:|.|.|::.|:....|:
Human   902 TPLPEGQTLQHDVPWQEGNREDGYLSGLNNLVDILTEM 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IP3K1	NP_609313.2	IPK	220..426	CDD:281727	87/210 (41%)
ITPKB	NP_002212.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..128
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..288
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..472
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..561
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	580..638		14/60 (23%)
		IPK	726..937	CDD:281727	87/210 (41%)
		Calmodulin-binding. /evidence=ECO:0000250	768..776		6/7 (86%)
		Substrate binding. /evidence=ECO:0000250	793..800		4/6 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D410791at33208
OrthoFinder	1	1.000	-	-		FOG0001484
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103318
Panther	1	1.100	-	-	O	PTHR12400
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.750