DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IP3K1 and Itpkc

DIOPT Version :9

Sequence 1:	NP_609313.2	Gene:	IP3K1 / 34300	FlyBaseID:	FBgn0032147	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_835195.1	Gene:	Itpkc / 308451	RGDID:	631336	Length:	678	Species:	Rattus norvegicus

Alignment Length:	321	Identity:	120/321 - (37%)
Similarity:	177/321 - (55%)	Gaps:	33/321 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 RSGQAPKNHIQAQDPAQMSLLKFLAINALELSAPATPHLLQHQQAHKQAKPQGWMQLSGHPESIV 171
            |||..|...::       ::||:            :|.::..   ||...|  |:|||||..:..
  Rat   377 RSGSKPWKKLK-------TVLKY------------SPFVVSF---HKHYYP--WVQLSGHAGNFQ 417

  Fly   172 PTSTGIVRKRISGLEDSEVHAYRLICKEPQTAQIVPAYFGIQEMQSQHFIELQDLLAGFRDPCVM 236
            ....|.:.||..   ..|..:..|:..:| ....||.|:|:.:...|.|.:::||||.|..|.:|
  Rat   418 AGEDGRILKRFC---QCEQRSLELLMGDP-LRPFVPTYYGMVQRDGQAFNQMEDLLADFEGPSIM 478

  Fly   237 DIKMGSRTFLESEVSNATLRP----DLYQKMIAVDAGAPTPAEHEARAITKLRYMTFRESLSSSH 297
            |.||||||:||.|:..|..||    |:|:||:|||.|||||.||...|:||.|||.:||:|||:.
  Rat   479 DCKMGSRTYLEEELVKARERPKPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETLSSTS 543

  Fly   298 SKGFRIEALRLRGRPPVKDLKTCRSSEQIAQTIEQFLAARRSVQKELLKRLKHMRLVIEQSTFFA 362
            :.|||||.::........:.|..::.||:.:.:|.|:.....:.::.:.||:.:|..:|.|.||.
  Rat   544 TLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVNGDVGILRKYVARLEDLRDTLENSPFFK 608

  Fly   363 SHEIIGSSIFIVYDDDRVG-VWLIDFAKCRELPPHVRVDHRSAWAPGNREEGLLRGMDELI 422
            :||::|||:..|:|...:. ||:|||.|...||.|..:.||..||.||||:|.|.|:|.||
  Rat   609 THEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQMLSHRLPWAEGNREDGYLWGLDNLI 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IP3K1	NP_609313.2	IPK	220..426	CDD:281727	93/208 (45%)
Itpkc	NP_835195.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..125
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..300
		Nuclear export signal	318..326
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..381		3/3 (100%)
		IPK	462..673	CDD:281727	93/208 (45%)
		Substrate binding. /evidence=ECO:0000250	502..508		2/5 (40%)
		Calmodulin-binding. /evidence=ECO:0000250	504..512		4/7 (57%)
		Substrate binding. /evidence=ECO:0000250	529..536		4/6 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344864
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D410791at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103318
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.650