DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IP3K1 and Itpkc

DIOPT Version :9

Sequence 1:	NP_609313.2	Gene:	IP3K1 / 34300	FlyBaseID:	FBgn0032147	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_853624.1	Gene:	Itpkc / 233011	MGIID:	2442554	Length:	678	Species:	Mus musculus

Alignment Length:	276	Identity:	114/276 - (41%)
Similarity:	162/276 - (58%)	Gaps:	11/276 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 HKQAKPQGWMQLSGHPESIVPTSTGIVRKRISGLEDSEVHAYRLICKEPQTAQIVPAYFGIQEMQ 216
            ||...|  |:|||||..:......|.:.||..   ..|..:..|:..:| ....||||:|:.:..
Mouse   400 HKHYYP--WVQLSGHAGNFQAGEDGRILKRFC---QCEQRSLELLMGDP-LRPFVPAYYGMVQRD 458

  Fly   217 SQHFIELQDLLAGFRDPCVMDIKMGSRTFLESEVSNATLRP----DLYQKMIAVDAGAPTPAEHE 277
            .|.|.:::||||.|..|.:||.||||||:||.|:..|..||    |:|:||:|||.|||||.||.
Mouse   459 GQAFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPKPRKDMYEKMVAVDPGAPTPEEHA 523

  Fly   278 ARAITKLRYMTFRESLSSSHSKGFRIEALRLRGRPPVKDLKTCRSSEQIAQTIEQFLAARRSVQK 342
            ..||||.|||.:||:|||:.:.|||||.::........:.|..::.||:.:.:|.|:.....:.:
Mouse   524 QGAITKPRYMQWRETLSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVNGDLGILR 588

  Fly   343 ELLKRLKHMRLVIEQSTFFASHEIIGSSIFIVYDDDRVG-VWLIDFAKCRELPPHVRVDHRSAWA 406
            :.:.||:.:|..:|.|.||.:||::|||:..|:|...:. ||:|||.|...||.|..:.||..|.
Mouse   589 KYVARLEDLRETLENSPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQMLSHRLPWT 653

  Fly   407 PGNREEGLLRGMDELI 422
            .||||:|.|.|:|.||
Mouse   654 EGNREDGYLWGLDNLI 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IP3K1	NP_609313.2	IPK	220..426	CDD:281727	93/208 (45%)
Itpkc	NP_853624.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..128
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..300
		Nuclear export signal. /evidence=ECO:0000250	318..326
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..380
		IPK	462..673	CDD:281727	93/208 (45%)
		Substrate binding. /evidence=ECO:0000250	502..508		2/5 (40%)
		Calmodulin-binding. /evidence=ECO:0000250	504..512		4/7 (57%)
		Substrate binding. /evidence=ECO:0000250	529..536		4/6 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841517
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D410791at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103318
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.650