DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IP3K1 and Itpka

DIOPT Version :9

Sequence 1:	NP_609313.2	Gene:	IP3K1 / 34300	FlyBaseID:	FBgn0032147	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_666237.1	Gene:	Itpka / 228550	MGIID:	1333822	Length:	459	Species:	Mus musculus

Alignment Length:	378	Identity:	140/378 - (37%)
Similarity:	190/378 - (50%)	Gaps:	60/378 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LDTSASSKQRSAMMLEVEQQQQQQQQQQSNNNNERIPNENCDYLSLQRSGQAPKNHIQAQDPAQM 124
            |.||:.|...|:.:||..:.......:..:..|.::...       :..||  |:|.|
Mouse   118 LSTSSLSSTGSSSLLEDSEDDLLSDSESRSRGNVQLETS-------EDVGQ--KSHWQ------- 166

  Fly   125 SLLKFLAINALELSAPATPHLLQHQQAHKQAKPQGWMQLSGHPESIVPTST-GIVRKRISGLEDS 188
               |...:..|.:.:|.             .|...|:||:||..|.....| |::.||     .|
Mouse   167 ---KIRTMVNLPVMSPF-------------RKRYSWVQLAGHTGSFKAAGTSGLILKR-----SS 210

  Fly   189 EVHAYRLI---------CKEPQTAQIVPAYFGIQEMQSQHFIELQDLLAGFRDPCVMDIKMGSRT 244
            |...|.|:         |        |||:.||.|...:.:::|||||.||..|||:|.|||.||
Mouse   211 EPEHYCLVRLMADVLRGC--------VPAFHGIVERDGESYLQLQDLLDGFDGPCVLDCKMGVRT 267

  Fly   245 FLESEVSNATLRP----DLYQKMIAVDAGAPTPAEHEARAITKLRYMTFRESLSSSHSKGFRIEA 305
            :||.|::.|..||    |:|:||:|||..|||..||..||:||.|||.:||.:|||.:.|||||.
Mouse   268 YLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEG 332

  Fly   306 LRLRGRPPVKDLKTCRSSEQIAQTIEQFLAARRSVQKELLKRLKHMRLVIEQSTFFASHEIIGSS 370
            ::........|.||.||.||:.:..|:|:.....|.:..|.||:.:|..:|.|.||..||:||||
Mouse   333 IKKADGSCSTDFKTTRSREQVTRVFEEFMQGDAEVLRRYLNRLQQIRDTLEISDFFRRHEVIGSS 397

  Fly   371 IFIVYDD-DRVGVWLIDFAKCRELPPHVRVDHRSAWAPGNREEGLLRGMDELI 422
            :..|:|. .|.|||||||.|...||....:|||..|..||||:|.|.|:|.||
Mouse   398 LLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLI 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IP3K1	NP_609313.2	IPK	220..426	CDD:281727	102/208 (49%)
Itpka	NP_666237.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..164		11/54 (20%)
		IPK	243..453	CDD:281727	102/208 (49%)
		Calmodulin-binding. /evidence=ECO:0000250	285..293		4/7 (57%)
		Substrate binding. /evidence=ECO:0000250	310..317		4/6 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841514
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4475
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D410791at33208
OrthoFinder	1	1.000	-	-		FOG0001484
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103318
Panther	1	1.100	-	-	O	PTHR12400
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.700