DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IP3K1 and si:ch73-22a13.3

DIOPT Version :9

Sequence 1:	NP_609313.2	Gene:	IP3K1 / 34300	FlyBaseID:	FBgn0032147	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	XP_021336768.1	Gene:	si:ch73-22a13.3 / 100333120	ZFINID:	ZDB-GENE-141216-64	Length:	602	Species:	Danio rerio

Alignment Length:	492	Identity:	137/492 - (27%)
Similarity:	224/492 - (45%)	Gaps:	95/492 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LQRPIQAKPEKKA------------------SSKSTSSSRSRSTMAWSN-------------EKL 41
            ||:|.:...::.|                  :||.|.::.:|.:: |.:             |:|
Zfish   132 LQKPKEGTKDEDAEEWRVQEKVMADGTSVGKASKVTLNAATRKSL-WRSKIEPKERPKEGMRERL 195

  Fly    42 R--FSCID-----NIGLKQLWKLIALDTSASSKQRSAMML-EVEQQQQQQQQQQSNNNNERIPNE 98
            :  |..||     :.|.|::.:    ..|.|||||..... ..:.:.......:.:...|.:|:.
Zfish   196 KGSFESIDESNEGDFGSKRIQR----KKSWSSKQRKTQTFGSRDGEHYMVGSMEKDGEKEVVPHP 256

  Fly    99 NCDYLSLQRSGQAPK--NHIQAQDPAQMSLLKFLAINALELSAPATPHLLQHQQAHKQAK----- 156
            ....:....|..:..  |:..|:.....|               .:...:..:|..|:.:
Zfish   257 VLSRVLFHSSASSSSSFNNSSAESDEVFS---------------ESEDTVARRQTMKKCRSWRTF 306

  Fly   157 ----------PQGWMQLSGHPESIVPTSTGIVRKRISGLEDSEVHAYRLICKE----PQTAQIVP 207
                      ...|:||:||..::..:..|.|.||...:||        ||.:    ....|.||
Zfish   307 LTMMQWSKRTQSSWIQLAGHQGNVRLSEGGEVLKRFCEVED--------ICLQALMSDALCQFVP 363

  Fly   208 AYFGIQEMQSQHFIELQDLLAGFRDPCVMDIKMGSRTFLESEVSNATLRP----DLYQKMIAVDA 268
            .|||......:.:|.|:|||:|.::|.:||.|||.||:.|:|:..|.:.|    |:||||:.||.
Zfish   364 HYFGHISQDGEKYIRLEDLLSGLKNPVIMDCKMGVRTYQEAEIIKARINPSVRTDMYQKMVKVDP 428

  Fly   269 GAPTPAEHEARAITKLRYMTFRESLSSSHSKGFRIEALRLRGRPPVKDL-KTCRSSEQIAQTIEQ 332
            .|||..|||.:.||||||:.:|::.||:.|.|||||.:.:.....::|. ||| :..|:.:|:..
Zfish   429 AAPTDEEHEQKGITKLRYLQWRDNSSSTSSLGFRIEGIVVGNGKVLRDFYKTC-TEAQVTETLLS 492

  Fly   333 FLAARRSVQKELLKRLKHMRLVIEQSTFFASHEIIGSSIFIVYD-DDRVGVWLIDFAKCRELPPH 396
            |...:..:.:....||:.:...::||:||..|||||||:..|:| :::..:|:|||.|...:|..
Zfish   493 FTRRQIHILEAYESRLQALYETLKQSSFFNKHEIIGSSLLFVHDRNNKANIWMIDFGKTIPVPED 557

  Fly   397 VRVDHRSAWAPGNREEGLLRGMDELIRSFEEVYARCG 433
            |::.|...|..||||:|.|.|:..||....|...:.|
Zfish   558 VQLSHDVPWVEGNREDGYLIGLTSLISLVREAIKQAG 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IP3K1	NP_609313.2	IPK	220..426	CDD:281727	86/211 (41%)
si:ch73-22a13.3	XP_021336768.1	IPK	376..587	CDD:309046	86/211 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585856
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1621
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D410791at33208
OrthoFinder	1	1.000	-	-		FOG0001484
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12400
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850