Protein Alignment ppk11 and ASIC3

DIOPT Version :10

• Sequence 1: NP_001334672.1
• Gene: ppk11 / 34299
• FlyBaseID: FBgn0065109
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_064717.1
• Gene: ASIC3 / 9311
• HGNCID: 101
• Length: 549
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 117/546 - (21%)
• Similarity: 190/546 - (34%)
• Gaps: 183/546 - (33%)

  Fly    95 IYCEMASIHGF-HIF-VGAKTWQRILWWLLICNAVLLSFTLVIMSLSMSKETPTIRFIDTMMKPT 157
            ::....|:||. |:| .|:.:.:|.:|    ..||:||....:..::     ..:|:.......|
Human    19 VFASNCSMHGLGHVFGPGSLSLRRGMW----AAAVVLSVATFLYQVA-----ERVRYYREFHHQT 74

  Fly   158 A-------EVPFPAVTICGF----------NTKEWMNSSQIVNQRNASWLELLEDLALPIC---- 201
            |       .:.|||||:|..          |...|..|: ::....|.....|..|..|..
Human    75 ALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSA-LLGLDPAEHAAFLRALGRPPAPPGF 138

  Fly   202 ---PQIKICQ--------WDNRMVNCLDQLQP-----IWTLDQRL--CCSFNY---NKQLFSS-- 243
               |...:.|        .|:.:::|..:.||     ..|:..|:  |.:||.   ..:|.::
Human   139 MPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTR 203

  Fly   244 -----------------YLGVSFVLRSNDEILQSSKSAGFEVLIHESHEIP------NGATP--R 283
                             ||.   |.|.|:|   :....|..|.||...|.|      .|.:|  :
Human   204 GGMGNGLDIMLDVQQEEYLP---VWRDNEE---TPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQ 262

  Fly   284 VFVPGESDAHIMLRPYINRFTKNLKGLSLQKRGCYFSTERRLIL-------SDVYNQINCLAECR 341
            .||..:......|.|...    :....||...   :..|....|       |..|..:.|...|.
Human   263 TFVSCQQQQLSFLPPPWG----DCSSASLNPN---YEPEPSDPLGSPSPSPSPPYTLMGCRLACE 320

  Fly   342 TESILKSCGC----IPPKSPIEKSWLICDLKQMQ-CVIDFDHDEIISGEQK-NCDCLPPCEFNRY 400
            |..:.:.|||    :|...|      :|..:|.: |.    |..|.:..:| :|.|..||...||
Human   321 TRYVARKCGCRMVYMPGDVP------VCSPQQYKNCA----HPAIDAMLRKDSCACPNPCASTRY 375

  Fly   401 EFQSDI---------RFIKGMINNSIVNTSNQETTNEVRVRVYYDSAIAEELL-LDVYENWLTF- 454
            ..:..:         ||:...:|.|                   ::.|||.:| ||::...|.:
Human   376 AKELSMVRIPSRAAARFLARKLNRS-------------------EAYIAENVLALDIFFEALNYE 421

  Fly   455 -------------IGTFGGITGLFMGCSFVSVFELIFFSCVRPTCNWLTRQQIL---WRRRRNQR 503
                         :|..||..|||:|.|.:::.|::.:.|.      :.|.::|   |.|:.:||
Human   422 TVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCE------VFRDKVLGYFWNRQHSQR 480

  Fly   504 --------VGITESR------SLGPA 515
                    .|:...|      ||||:
Human   481 HSSTNLLQEGLGSHRTQVPHLSLGPS 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk11	NP_001334672.1	ASC	96..479	CDD:459966	104/490 (21%)
ASIC3	NP_064717.1	ENaC	20..534	CDD:273304	117/545 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..307		4/24 (17%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	447..449		1/1 (100%)