DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk11 and Asic4

DIOPT Version :9

Sequence 1:	NP_001334672.1	Gene:	ppk11 / 34299	FlyBaseID:	FBgn0065109	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_071570.2	Gene:	Asic4 / 63882	RGDID:	621068	Length:	539	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	107/499 - (21%)
Similarity:	181/499 - (36%)	Gaps:	119/499 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 YCEMASIHGF--HIFVGAKTWQRILWWLLICNAVLLSFTLVIMSLSMSKET-PTIRFIDTMMKPT 157
            :...:::||.  ....|....:|.||.|.:..: |.:|.....||:....| |.:    ..|.|.
  Rat    45 FASTSTLHGLGRACGPGPHGLRRTLWVLALLTS-LAAFLYQAASLARGYLTRPHL----VAMDPA 104

  Fly   158 AEVP---FPAVTICGFN--TKEWMNSSQIVNQRNASWL---------------------ELLEDL 196
            |..|   |||||:|..|  ....::.:.|.:..|.:.|                     ::|...
  Rat   105 APAPVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRT 169

  Fly   197 ALPICPQIKICQWDNRMVNC-LDQLQPIWTLDQRLCCSFNYNKQL--------FSSYLGVSFVLR 252
            ...:...:|.|.:...  :| ......::|...: |.:||.:.|.        ..|.|.:...::
  Rat   170 GHQLADMLKSCNFSGH--HCSASNFSVVYTRYGK-CYTFNADPQSSLPSRAGGMGSGLEIMLDIQ 231

  Fly   253 SND------EILQSSKSAGFEVLIHES------HEIPNGATP--RVFVPGESDAHIML-RPYIN- 301
            ..:      |..::|..||..|.||..      |::..|.:|  :.||..:......| :|:.|
  Rat   232 QEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNC 296

  Fly   302 RFTKNLKGLSLQKRGCYFSTERRLILSDVYNQINCLAECRTESILKSCGCIPPKSPIEKSWLICD 366
            |....|:...||....|..:.             |...|..|::|:.|.|.....|..::  ||.
  Rat   297 RAESKLREPELQGYSAYSVSA-------------CRLRCEKEAVLQRCHCRMVHMPGNET--ICP 346

  Fly   367 LK-QMQCVIDFDH--DEIISGEQKNCDCLPPCEFNRYEFQSDIRFIKGMINNSIVNTSNQETTNE 428
            .. .::|.   ||  |.:..|.:..|.|..||...||  ..:|..:|.....|....:.:...||
  Rat   347 PNIYIECA---DHTLDSLGGGSEGPCFCPTPCNLTRY--GKEISMVKIPNRGSARYLARKYNRNE 406

  Fly   429 VRVRVYYDSAIAEELLLDVYENWLT--------------FIGTFGGITGLFMGCSFVSVFELIFF 479
            ..:|..:       |:|||:...||              .:|..||..|||:|.|.:::.|::.:
  Rat   407 TYIRENF-------LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDY 464

  Fly   480 SCVRPTCNWLTRQQILWRRRRN---------QRVGITESRSLGP 514
            ..   ..:| .|.:.:|||.:.         ..:|:.|.:...|
  Rat   465 IY---EVSW-DRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSP 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk11	NP_001334672.1	None
Asic4	NP_071570.2	ASC	40..488	CDD:295594	104/481 (22%)
Asic4	NP_071570.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..531		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345690
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840