DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk11 and Asic5

DIOPT Version :9

Sequence 1:	NP_001334672.1	Gene:	ppk11 / 34299	FlyBaseID:	FBgn0065109	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_071563.1	Gene:	Asic5 / 63866	RGDID:	69295	Length:	495	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	111/517 - (21%)
Similarity:	186/517 - (35%)	Gaps:	163/517 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 KILRWYNRVSKRFEEFPLPKFLGFLQARNDDGLCKRKTGFEIYCEMASIHGFHIFVGAKTWQRIL 118
            ||.|:   :|||    |||       :..|     ||.....:....|.||.|.....:...|.:
  Rat    18 KIRRY---LSKR----PLP-------SPTD-----RKKFDHDFAISTSFHGIHNIAQNQNKVRKV 63

  Fly   119 WWLLICNAVLLSFTLVIMSLSMSKETPTIRFIDTMMKPTA---------EVPFPAVTICGFNTKE 174
            .||   :.||.|.:|::..:..       |.::..|.||.         ::.|||||.|..|..:
  Rat    64 IWL---SVVLGSVSLLVWQIYS-------RLVNYFMWPTTTSIEVQYVEKIEFPAVTFCNLNRFQ 118

  Fly   175 -------------WMNSSQIV--------------------NQRNASWLELLEDLALPICPQIKI 206
                         |...|:::                    :.||.|..|.:::....:.....:
  Rat   119 TEAVSRFGIIFFLWDIVSKVLRLQEISGNNTGSPEALDFVASHRNFSITEFVKNNGFYLNHDTLV 183

  Fly   207 -CQWDNRMVNCLDQLQPIWTLDQRLCCSFNYNKQLFSSYLGVSFVLRSNDEILQSSKSAGFEVLI 270
             |::..:..:..| .:.::| :...|.:|||.:.           ::|.:::..|.:.....:.:
  Rat   184 HCEFFGKTCDPKD-FKHVFT-EYGNCFTFNYGEN-----------VQSKNKVSVSGRGLKLLLDV 235

  Fly   271 HESHEIPNGATPRVFVPGESDAHIMLRPYINRFTKNLKGLSLQKR-GCYFSTERRLILS------ 328
            |:.....|.      |||.:||.::...:..:......||.|... |.:.....|.:.:
  Rat   236 HQEEFTDNP------VPGFADAGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTIHQEYP 294

  Fly   329 ------DV-------YNQINCLAECRTESILKSCGCIP---PKSPIEKSWLICD-LKQMQCVID- 375
                  |:       |:...||.||:.:.|.:.|||:|   |.:.:|     || ||...||..
  Rat   295 WGECNPDIKLRNFTTYSTYGCLKECKAKHIQRLCGCLPFLLPGNGVE-----CDLLKYYNCVSPI 354

  Fly   376 FDHDE---IISGEQKNCDCLPPCE---------FNRYEFQSDIRFIKGMINNSIVNTSNQETTNE 428
            .||.|   :.:....|..|..|||         ::.:..|...:|:...:|.|      ||...|
  Rat   355 LDHIERKGLCTMGTHNSSCPVPCEETEYPATIAYSTFPSQRATKFLAKKLNQS------QEYIRE 413

  Fly   429 --VRVRVYYD-----------SAIAEELLLDVYENWLTFIGTFGGITGLFMGCSFVSVFELI 477
              |.:.:.|.           :....|||.||           ||..|||.|.|.:::.|:|
  Rat   414 NLVNIEINYSDLNYKITQQQKAVSVPELLADV-----------GGQLGLFCGASLITIIEII 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk11	NP_001334672.1	None
Asic5	NP_071563.1	deg-1	40..465	CDD:273309	99/476 (21%)
Asic5	NP_071563.1	ASC	41..466	CDD:279230	99/475 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810