DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk11 and SCNN1G

DIOPT Version :10

Sequence 1:NP_001334672.1 Gene:ppk11 / 34299 FlyBaseID:FBgn0065109 Length:516 Species:Drosophila melanogaster
Sequence 2:NP_001030.2 Gene:SCNN1G / 6340 HGNCID:10602 Length:649 Species:Homo sapiens


Alignment Length:573 Identity:105/573 - (18%)
Similarity:193/573 - (33%) Gaps:202/573 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 YCEMASIHGF-HIFVGAKTWQRILW--------WLLICNAVLLSFTLVIMSLSMSKETPTIRFID 151
            ||...:.||. .|.|.....:|:||        .|::....||.|:...:|:|:.     :.|  
Human    32 YCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFSFYTVSVSIK-----VHF-- 89

  Fly   152 TMMKPTAEVPFPAVTICGFN-----------------TKEWMNS----SQIVNQRNA-SWLELLE 194
                  .::.|||||||..|                 |:|.:.|    .:...:|.| ||..:.|
Human    90 ------RKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAESWNSVSE 148

  Fly   195 D--------LALPICPQ--------------------------------------IKICQWD--- 210
            .        :.|.|..|                                      .::|..|   
Human   149 GKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSNDTSD 213

  Fly   211 ------NRMVNCLDQLQPIW------------TLDQRLCCSFNYNKQLFSSYL-GVS-----FVL 251
                  :..:|.:.:    |            .|::::..|::..:.|.:.:. |||     |.|
Human   214 CATYTFSSGINAIQE----WYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTL 274

  Fly   252 --------------RSNDEILQSSKSA---GFEVLIHESHEIPNGATPRVFVPGESDAHIMLR-- 297
                          |.|:.||.:|...   |.:|:::.:.|..|     .|:...:.|.:::.  
Human   275 FHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYN-----PFLVSSTGAKVIIHRQ 334

  Fly   298 ---PYINRFTKNLKGLSLQKRGCYFSTERRLI--------------LSDVYN-----QINCLAEC 340
               |::......::...:...|.:.:...:|.              :.::||     || ||..|
Human   335 DEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQI-CLHSC 398

  Fly   341 RTESILKSCGCIPPKSPIEKSWLICDLKQ----MQCVIDFDHDEIISGEQKNCD--CLPPCEFNR 399
            ....:::.|||.....|:..:...|:.:|    |.|.... |...:. |:..|.  |...|.|..
Human   399 FQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQL-HRAFVQ-EELGCQSVCKEACSFKE 461

  Fly   400 YEFQSDIRFIKGMINNS---IVNTSNQ--------ETTNEVRVRVYYDSAIAEELLLDVYENWLT 453
            :...:.:.....:::..   .|.|.:|        ..|:..::.::|.......::.....:...
Human   462 WTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEM 526

  Fly   454 FIGTFGGITGLFMGCSFVSVFELI------FFSCVRPTCNWLTRQQILWRRRR 500
            .:..|||..||:|.||.|.|.|:|      |||.:       .|:|  |::.:
Human   527 LLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSII-------ARRQ--WQKAK 570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk11NP_001334672.1 ASC 96..479 CDD:459966 99/550 (18%)
SCNN1GNP_001030.2 ENaC 24..630 CDD:273304 105/573 (18%)
Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000269|PubMed:30251954, ECO:0000269|PubMed:32729833 135..221 10/85 (12%)
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:17502380 623..627
Blue background indicates that the domain is not in the aligned region.

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