Protein Alignment ppk11 and SCNN1D

DIOPT Version :9

• Sequence 1: NP_001334672.1
• Gene: ppk11 / 34299
• FlyBaseID: FBgn0065109
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 89/561 - (15%)
• Similarity: 174/561 - (31%)
• Gaps: 205/561 - (36%)

  Fly    70 PLPKFLGFLQARNDDGLCKRKTGFE----IYCEMASIHGFHIFVGAK--TWQRILWWLLICNA-V 127
            |.||      ..:.:||.:....|.    .:|..|:|||....|.::  ..:...|.||...| |
Human   203 PPPK------EGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALV 261

  Fly   128 LLSFTL-----------VIMSLSMSKETPTIRFIDTMMKPTAEVPFPAVTICGFNTKEWMNSSQI 181
            .|.:.|           |:|::|:..|...:               |.||:|..|.:   ..|.:
Human   262 ALCWQLGLLFERHWHRPVLMAVSVHSERKLL---------------PLVTLCDGNPR---RPSPV 308

  Fly   182 VNQRNASWLELLEDLA---LPICPQIKICQWDNRMVNCLDQLQPIWTLDQ--------------- 228
            :..     ||||::.|   :.....:.:.:....:...:.:.:|.:.||:
Human   309 LRH-----LELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVR 368

  Fly   229 ---RLC----------------------------------------------------CSFN--- 235
               |||                                                    ||::
Human   369 VGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLD 433

  Fly   236 ---------YNKQLFSSYL--------------GVSFVLRSNDE--ILQSSKSAGFEVLIHESHE 275
                     ::....|.|.              ||..|||...:  :...|..||..|::|..:.
Human   434 CQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNH 498

  Fly   276 IP---------NGATPRVFVPGESDAHIMLRPYINRFTKNLKGLSLQKRGCYFSTERRLILSDVY 331
            .|         ...|.......|.:.|.:..|| ...|...:|:.::           |:.:..|
Human   499 TPFLGHHSFSVRPGTEATISIREDEVHRLGSPY-GHCTAGGEGVEVE-----------LLHNTSY 551

  Fly   332 NQINCLAECRTESILKSCGC------IPP-----KSPIEKSWLICDLKQMQCVIDFDHDEIISGE 385
            .:..||..|..:.::::|.|      :|.     .|....:|..|..:..|   |.:...:....
Human   552 TRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQ---DLETHRLPCTS 613

  Fly   386 QKNCDCLPPCEFNRYEFQSDIR----------FIKGMINNSIVNTSNQETTNEVRVRVYYDS--- 437
            :    |..||..:.::..:...          .:..:....:.:.|:::.::..::.:.|..
Human   614 R----CPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNY 674

  Fly   438 -AIAEELLLDVYENWLTFIGTFGGITGLFMGCSFVSVFELI 477
             ::.|..:..|.:    .:...|.:..|:.|.|.:|:.||:
Human   675 RSVEEAPVYSVPQ----LLSAMGSLCSLWFGASVLSLLELL 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk11	NP_001334672.1	None
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		3/13 (23%)
		ENaC	219..784	CDD:273304	84/539 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152179
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740