Protein Alignment ppk11 and SCNN1A

DIOPT Version :10

• Sequence 1: NP_001334672.1
• Gene: ppk11 / 34299
• FlyBaseID: FBgn0065109
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 107/557 - (19%)
• Similarity: 172/557 - (30%)
• Gaps: 219/557 - (39%)

  Fly    93 FEIYCEMASIHGF-------HIFVGAKTWQRILWWLLICNAVLLSFTLVI-------MSLSMSKE 143
            ||.:|...:|||.       |..:....|  .:.||.....:...|.|:.       :||:::..
Human   118 FEFFCNNTTIHGAIRLVCSQHNRMKTAFW--AVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLN 180

  Fly   144 TPTIRFIDTMMKPTAEVPFPAVTICGFN-------TKEWMNSSQIVNQ------RNASWLEL--- 192
            :.             ::.|||||||..|       .:|.....:|..|      :.:|:..|
Human   181 SD-------------KLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAG 232

  Fly   193 --------------LEDLALP---------------------------------ICPQIK----- 205
                          |:.|.:|                                 :|.|.|
Human   233 SRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFY 297

  Fly   206 ---------ICQWDN-RMVNCLDQL-QPIWTLDQR------LCCSFNY----------------- 236
                     :.:|.. ..:|.|.:| :.:.:|::.      ..|.||.
Human   298 QTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYG 362

  Fly   237 ---------NKQLFSSYL-----GVSFVLRS--NDEILQSSKSAGFEVLIHESHEIP-----NGA 280
                     |..|:.|.:     |:|.:||:  ||.|...|...|..|::|...| |     .|.
Human   363 NCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDE-PAFMDDGGF 426

  Fly   281 TPRVFVPGESDAHIMLRPYINRF-------TKNLKGLSLQKRGCYFSTERRLILSDVYNQINCLA 338
            ..|   ||...:..|.:..::|.       |||  |..:.....|.|.         |.|..|:.
Human   427 NLR---PGVETSISMRKETLDRLGGDYGDCTKN--GSDVPVENLYPSK---------YTQQVCIH 477

  Fly   339 ECRTESILKSCGC----IPPKSPIE-------KSWLICDLKQMQCVIDFDHDEIISGEQKNC--D 390
            .|..||::|.|||    .|....:|       .||..|..|..   :||..|.:      .|  .
Human   478 SCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQ---VDFSSDHL------GCFTK 533

  Fly   391 CLPPCEFNRYEFQSDI---------RFIKGMINNSIVNTSNQETTNEVRVRVYYDSAIAEELLLD 446
            |..||....|:..:..         .::..|::.....|.|.:.....:|.:::..       |:
Human   534 CRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKE-------LN 591

  Fly   447 VYEN-------WLTFIGTFGGITGLFMGCSFVSVFEL 476
            ...|       .:|.:...|....|:.|.|.:||.|:
Human   592 YKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEM 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk11	NP_001334672.1	ASC	96..479	CDD:459966	105/554 (19%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	107/557 (19%)