DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk11 and asic1b

DIOPT Version :9

Sequence 1:	NP_001334672.1	Gene:	ppk11 / 34299	FlyBaseID:	FBgn0065109	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_999956.1	Gene:	asic1b / 407672	ZFINID:	ZDB-GENE-040513-1	Length:	557	Species:	Danio rerio

Alignment Length:	458	Identity:	99/458 - (21%)
Similarity:	184/458 - (40%)	Gaps:	127/458 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 SIHGF-HIFVGAKTW--QRILWWLLICNAVLLSFTLVIMSLSMSKETPTIRFIDTMMKPTAEVPF 162
            |:||. |:||..|.:  ::.||.|:...|:.:....|:..:....:...:..:|.  :....:.|
Zfish    74 SLHGANHVFVEDKKFSIRQGLWALVFLLAISMFLLQVVDRVIYYLQYDYVTLLDE--RNAKNMTF 136

  Fly   163 PAVTICGFNTKEWMNSSQIVNQRNASWLELL---------EDLA--LPICPQ-------IKICQW 209
            ||:|:|.:||   ...||:      |:.:||         :::|  :|:.|:       ..:.::
Zfish   137 PAITLCNYNT---FRRSQL------SYSDLLFMGPLLGYEDNMAPGIPLAPEPDRQGSRFSLAEF 192

  Fly   210 DNRMVNCLDQLQPIWTLDQRLCCSF-------NYNKQLFSSYLGVSFVLRSNDE---ILQSSKSA 264
            .||..:.:|        |..|.|:|       .:.:::|:.| |..:...|..:   :|.::|..
Zfish   193 FNRTRHRMD--------DMLLECNFAGKECGAEHWREIFTRY-GKCYTFNSGQDGRPLLITTKGG 248

  Fly   265 ---GFEVL--IHESHEIPNGATPRVFVPGESD-----AHIMLR-------PYINRFTKNLKGLSL 312
               |.|::  |.:...:|        |.||:|     |.|.::       |:|::.     |..:
Zfish   249 MGNGLEIMLDIQQDEYLP--------VWGETDETTFEAGIKVQIHTQDEPPFIDQL-----GFGV 300

  Fly   313 QKRGCYFST-----ERRL--------------ILSDVYNQIN---CLAECRTESILKSCGC---- 351
            ...   |.|     |:||              |.||.:|..:   |..:|.|..::::|.|
Zfish   301 APG---FQTFVSCQEQRLTYLPPPWGDCKATPIDSDFFNTYSITACRIDCETRYLVENCNCRMVH 362

  Fly   352 IPPKSPIEKSWLICDLKQMQCVIDFDHDEIISGEQKNCDCLPPCEFNRYEFQSDIRFIKGMINNS 416
            :|..:|      .|..:|.:...|...|.::..:...|.|..||...||  ..::.|::.....|
Zfish   363 MPGDAP------YCTPEQYKECADPALDFLVERDNDYCVCETPCNMTRY--GKELSFVRIPSKAS 419

  Fly   417 I------VNTSNQETTNEVRVRVYYDSAIAEELL--LDVYENWLTFIGTFGGITGLFMGCSFVSV 473
            .      .|.:.|..::.:.|...:..|:..|.:  ...|| ....:|..||..|||:|.|.:::
Zfish   420 AKYLAKKYNKTEQYISDNIMVLDIFFEALNYETIEQKKAYE-LAGLLGDIGGQMGLFIGASILTI 483

  Fly   474 FEL 476
            .||
Zfish   484 LEL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk11	NP_001334672.1	None
asic1b	NP_999956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..57
		ASC	66..548	CDD:295594	99/458 (22%)
		Selectivity filter. /evidence=ECO:0000305	477..479		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586667
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940