DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk11 and ASIC2

DIOPT Version :9

Sequence 1:	NP_001334672.1	Gene:	ppk11 / 34299	FlyBaseID:	FBgn0065109	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_899233.1	Gene:	ASIC2 / 40	HGNCID:	99	Length:	563	Species:	Homo sapiens

Alignment Length:	495	Identity:	102/495 - (20%)
Similarity:	168/495 - (33%)	Gaps:	175/495 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 ASIHGFHIFVGAKT------WQRILWWLLICNA--VLLSFT--LVIMSLSMSKETPTIRFIDTMM 154
            |.:||.......:|      .:|.||.|..|.:  :|||::  .::..||....|...|
Human    64 AKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSSNRLLYWLSFPSHTRVHR------ 122

  Fly   155 KPTAEVPFPAVTICGFNTKEWMNSSQ------------IVNQRNA---------------SWLEL 192
            :.:.::||||||:|..|...:...|:            ::..|.|               .|...
Human   123 EWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRK 187

  Fly   193 LEDLALPICPQ----IKICQWDNRMVNCLDQLQPIWTLDQRLCCSFNYNKQLFSSYLGVSFVLRS 253
            |.|..|.:.|:    |.....| |:.:.|:.:.........||...|:: .:|:.| |..::..|
Human   188 LADFRLFLPPRHFEGISAAFMD-RLGHQLEDMLLSCKYRGELCGPHNFS-SVFTKY-GKCYMFNS 249

  Fly   254 --------------------------NDEIL-------QSSKSAGFEVLIHESHEIP------NG 279
                                      .||.|       :::..||.:|.||...|.|      .|
Human   250 GEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFG 314

  Fly   280 ATP--RVFVPGESDAHIMLRPYINRFTKNLKGLSLQKRGCYFSTERRLILSDVYNQINCLAECRT 342
            ..|  :.||..:......|.|               ..|...|:|..|....||:...|..:|.|
Human   315 VAPGFQTFVATQEQRLTYLPP---------------PWGECRSSEMGLDFFPVYSITACRIDCET 364

  Fly   343 ESILKSCGC----IPPKSPIEKSWLICDLKQMQCVIDFDHDE-------IISGEQKN-CDCLPPC 395
            ..|:::|.|    :|..:|      .|..:|        |.|       :::.:..| |.|..||
Human   365 RYIVENCNCRMVHMPGDAP------FCTPEQ--------HKECAEPALGLLAEKDSNYCLCRTPC 415

  Fly   396 EFNRYE---------FQSDIRFIKGMINNSIVNTSNQETTNEVRVRVYYDSAIAEELL-LDVYEN 450
            ...||.         .::..::::...|.|                   :..|:|.:| ||::..
Human   416 NLTRYNKELSMVKIPSKTSAKYLEKKFNKS-------------------EKYISENILVLDIFFE 461

  Fly   451 WLTF--------------IGTFGGITGLFMGCSFVSVFEL 476
            .|.:              :|..||..|||:|.|.:::.||
Human   462 ALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILEL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk11	NP_001334672.1	None
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	102/495 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152153
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840