DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk11 and Scnn1b

DIOPT Version :9

Sequence 1:	NP_001334672.1	Gene:	ppk11 / 34299	FlyBaseID:	FBgn0065109	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001258952.1	Gene:	Scnn1b / 20277	MGIID:	104696	Length:	638	Species:	Mus musculus

Alignment Length:	586	Identity:	105/586 - (17%)
Similarity:	187/586 - (31%)	Gaps:	227/586 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 YCEMASIHGFHIFVGAKTWQRILWWL-------LIC--NAVLLSFTL---VIMSLSMSKETPTIR 148
            ||...:.||....:.....::.:|:|       |:|  ..|.:...|   |.:||||..:|
Mouse    29 YCNNTNTHGPKRIICEGPKKKAMWFLLTLLFACLVCWQWGVFIQTYLSWEVSVSLSMGFKT---- 89

  Fly   149 FIDTMMKPTAEVPFPAVTICG----------------------------------FNTKEWMNSS 179
                       :.|||||:|.                                  .||...:|.:
Mouse    90 -----------MNFPAVTVCNSSPFQYSKVKHLLKDLDELMEAVLEKILAPEASHSNTTRTLNFT 143

  Fly   180 -------QIVNQRNASW---LELLED-------------------LALPIC-PQIKIC------- 207
                   .::::||...   |.|..|                   :|:.:| ....:|
Mouse   144 IWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLCSANGTVCTLRNFTS 208

  Fly   208 ------QW------------------------DNRMVNCL--------DQLQPIWTLDQRLCCSF 234
                  :|                        |..::.||        ....||:..|...|..|
Mouse   209 ATQAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIF 273

  Fly   235 NY---NKQLFSSYLGVSFVLR------SNDEILQSSKSAGFEVLIHESHEIPNGATPRVFVPGES 290
            |:   .:.|.|:..|..|.|:      ..|.:...:.:||..:::||....|       |:..|.
Mouse   274 NWGMTEETLPSANPGTEFGLKLILDIGQEDYVPFLASTAGARLMLHEQRTYP-------FIREEG 331

  Fly   291 DAHIMLRPYINRFTKNLKGL---SLQKRGCYFS----TERRLILSDVYNQIN-------CLAECR 341
                   .|....|:...|:   .||::|..:|    ....:.:.::|:..|       ||..|.
Mouse   332 -------IYAMAGTETSIGVLVDKLQRKGEPYSPCTMNGSDVAIKNLYSVYNTTYSIQACLHSCF 389

  Fly   342 TESILKSCGC---IPPKSPIEK--------SWLICDLKQMQCVIDFDHDEIISGEQKNC--DCLP 393
            .:.::::|.|   :.|....||        .|..|.|.....|.          :::.|  .|..
Mouse   390 QDHMIRNCSCGHYLYPLPEGEKYCNNRDFPDWAYCYLNLQMSVT----------QRETCLSMCKE 444

  Fly   394 PCEFNRYEF---------QSDIRFIKGMINNSIVNTSNQETTNE--VRVRVYYDS----AIAEEL 443
            .|...:|:.         ::...:|..:::.....:||...:.:  |::.:|:..    .|.|..
Mouse   445 SCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYFQEFNYRTIEESP 509

  Fly   444 LLDVYENWLTFIGTFGGITGLFMGCSFVSVFEL--IFFSCVRPTCNWLTRQQIL-----WRRRRN 501
            ..::.  ||  :...||..|.:||.|.:.:.|.  |....:     |:|..:::     .||||.
Mouse   510 ANNIV--WL--LSNLGGQFGFWMGGSVLCLIEFGEIIIDFI-----WITIIKLVASCKGLRRRRP 565

  Fly   502 Q 502
            |
Mouse   566 Q 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk11	NP_001334672.1	None
Scnn1b	NP_001258952.1	ENaC	21..621	CDD:273304	105/586 (18%)
		deg-1	29..538	CDD:273309	96/551 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842216
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3633
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.770