| Sequence 1: | NP_001334672.1 | Gene: | ppk11 / 34299 | FlyBaseID: | FBgn0065109 | Length: | 516 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_035454.3 | Gene: | Scnn1a / 20276 | MGIID: | 101782 | Length: | 699 | Species: | Mus musculus |
| Alignment Length: | 132 | Identity: | 23/132 - (17%) |
|---|---|---|---|
| Similarity: | 41/132 - (31%) | Gaps: | 62/132 - (46%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 21 NLFNELF------LDRPFPQSNRVGSYYDRKPRMWYALN----------------HKGSMVRPNG 63
Fly 64 --------DDKGAAR---------------------------VKPRGTGVFLPERPVSSSQEKLN 93
Fly 94 NK 95 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| ppk11 | NP_001334672.1 | ASC | 96..479 | CDD:459966 | 23/132 (17%) |
| Scnn1a | NP_035454.3 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..71 | ||
| ENaC | 79..676 | CDD:273304 | 23/132 (17%) | ||
| Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000305|PubMed:18650438 | 200..270 | 10/62 (16%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 211..244 | 1/32 (3%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 637..699 | ||||
| PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P37088 | 669..673 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||