DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17633 and ECM14

DIOPT Version :9

Sequence 1:	NP_609310.2	Gene:	CG17633 / 34297	FlyBaseID:	FBgn0032144	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_012000.1	Gene:	ECM14 / 856533	SGDID:	S000001174	Length:	430	Species:	Saccharomyces cerevisiae

Alignment Length:	447	Identity:	130/447 - (29%)
Similarity:	208/447 - (46%)	Gaps:	76/447 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLNKCLLFALLAIVASASVSAERVRYDNYRMYKVNSENAKQL--EVLKDLEGSSD----SIMFLD 60
            ||..|.||.|||:  :.:|...:..|..|.:|:..|:|...|  :|:..|....|    |..|:|
Yeast     6 SLWGCFLFVLLAV--TGAVQGLQEDYSEYAVYRFTSDNYSTLVRDVIAPLTDDYDVWTRSNNFID 68

  Fly    61 GVHLVGADIQIIVAPHKVPDFLEILGKSEIKYELQSRDVQKSLDEIDEKV-------AIKGRATT 118
                       |..|.::.:              |..|.|..:|.::|.:       .:..|...
Yeast    69 -----------IKLPKEIGE--------------QINDGQVIIDNMNELIQNTLPTSQMMAREQA 108

  Fly   119 AYN------WAQYYELDDTYAWLQSLAQTNPGVVTLIEGGKTYQGRSILGVKITKGGETINGKAK 177
            .:.      :.:|.:||..|.||..|.::.|.:|.:...|:|::||.:..:.|: |.:..:...|
Yeast   109 VFENDYDFFFNEYRDLDTIYMWLDLLERSFPSLVAVEHLGRTFEGRELKALHIS-GNKPESNPEK 172

  Fly   178 PGIFLEAGIHAREWIAPAAATFIINQLLTSEVENIKE--LAENYTWYVLPHANPDGYVYTHTTNR 240
            ..|.:..||||||||:.:...:.:.|||.....:.||  ..::..:.|:|..|||||.||.:.:|
Yeast   173 KTIVITGGIHAREWISVSTVCWALYQLLNRYGSSKKETKYLDDLDFLVIPVFNPDGYAYTWSHDR 237

  Fly   241 LWRKT--RTPYGSCFGADPNRNWGFHWNEVGASSSACSDTYAGPSAFSEIETLSLSKFIEGLKG- 302
            ||||.  ||....|.|.|.:.::||.|.:  |.:.|||:.|:|.:.|...|..:..|:|...||
Yeast   238 LWRKNRQRTHVPQCLGIDIDHSFGFQWEK--AHTHACSEEYSGETPFEAWEASAWYKYINETKGD 300

  Fly   303 -KVQLYLSLHAYSQYLLYPYGHTSD-LPDNVADFEKVFDASIA---AVNKRYGTTY--------T 354
             |:..|:.:|:|||.:||||.::.| ||   .|.|.:.:.|..   |:..:.|..|        .
Yeast   301 YKIYGYIDMHSYSQEILYPYAYSCDALP---RDLENLLELSYGLSKAIRSKSGRNYDVISACKDR 362

  Fly   355 GGNIYDAIYPAAGASVDWAYGTQDVRMAFCYELRPSSTSYLTGFKLPAEQIVPASEE 411
            |.:|:..:  .||:::|:.|..: ...||..:||.:...   ||.||.|.|.|..:|
Yeast   363 GSDIFPGL--GAGSALDFMYHHR-AHWAFQLKLRDTGNH---GFLLPPENIKPVGKE 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17633	NP_609310.2	MpaA	7..374	CDD:225421	114/403 (28%)
		Propep_M14	34..105	CDD:280416	14/76 (18%)
		M14_CP_A-B_like	125..423	CDD:199844	101/305 (33%)
ECM14	NP_012000.1	M14_CP_A-B_like	121..425	CDD:349433	101/305 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1851
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		otm46499
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
TreeFam	0	0.000	Not matched by this tool.
	9	8.790