DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17633 and AGBL2

DIOPT Version :9

Sequence 1:	NP_609310.2	Gene:	CG17633 / 34297	FlyBaseID:	FBgn0032144	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_079059.2	Gene:	AGBL2 / 79841	HGNCID:	26296	Length:	902	Species:	Homo sapiens

Alignment Length:	335	Identity:	66/335 - (19%)
Similarity:	121/335 - (36%)	Gaps:	108/335 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 YELDDTYAWLQSLAQTNP------GVVTLIEGGKTYQGRSILGVKITKGGET-INGKAKPGIFLE 183
            |...|...:|.|:| .||      .:.||.   ::..|.::..:.||...:| ....||..:.|.
Human   398 YTYTDLQCYLLSVA-NNPIQSQFCKLQTLC---RSLAGNTVYLLTITNPSQTPQEAAAKKAVVLS 458

  Fly   184 AGIHARE----WIAPAAATFIINQLLTSEVENIKELAENYTWYVLPHANPDGYVYTHTTNRLWRK 244
            |.:|..|    |:......||:     |...:.:.|.:.:.:.|||..||||.:..:     :|
Human   459 ARVHPGESNGSWVMKGFLDFIL-----SNSPDAQLLRDIFVFKVLPMLNPDGVIVGN-----YR- 512

  Fly   245 TRTPYGSCFGADPNRNWGFHWNEVGASSSACSDTYAGPSAFSEIETLSLSKFIEGLKGKVQLYLS 309
                 .|..|.|.||    |:..:...|..|. .|.         ...:.:.:|  :.:|.||..
Human   513 -----CSLAGRDLNR----HYKTILKESFPCI-WYT---------RNMIKRLLE--EREVLLYCD 556

  Fly   310 LHAYS-QYLLYPYGHTSDLPDNVADFEKVFDASIAAVNKRYGTTYTGGNIYDAIYP---AAGASV 370
            .|.:| :..::.||..::                   |::|.       :::.::|   ...|..
Human   557 FHGHSRKNNIFLYGCNNN-------------------NRKYW-------LHERVFPLMLCKNAPD 595

  Fly   371 DWAYGTQDVRMAFCYELRPSSTSYLTGFKLPAEQIVPASEELLDSIVAMAT-------------- 421
            .:::.:.:.::..|.|        .||      ::|.....:|:|....:|
Human   596 KFSFHSCNFKVQKCKE--------GTG------RVVMWRMGILNSYTMESTFGGSTLGNKRDTHF 646

  Fly   422 ---EVKSLGY 428
               ::|||||
Human   647 TIEDLKSLGY 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17633	NP_609310.2	MpaA	7..374	CDD:225421	53/262 (20%)
		Propep_M14	34..105	CDD:280416
		M14_CP_A-B_like	125..423	CDD:199844	61/328 (19%)
AGBL2	NP_079059.2	GVQW	105..>120	CDD:290611
		M14_AGBL2-3_like	407..666	CDD:133117	64/326 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..879
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900