DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17633 and cpa2

DIOPT Version :9

Sequence 1:	NP_609310.2	Gene:	CG17633 / 34297	FlyBaseID:	FBgn0032144	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001003446.2	Gene:	cpa2 / 445052	ZFINID:	ZDB-GENE-040801-182	Length:	422	Species:	Danio rerio

Alignment Length:	426	Identity:	153/426 - (35%)
Similarity:	246/426 - (57%)	Gaps:	44/426 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CL-LFALLAIVASASVSAERVRYDNYRMYKVNSENAKQLEVLKDLEGSSDSIMFLDGVHLV-GAD 68
            |: :|.||     .:|..|.: ::..::.::::|:...::|||:||..|....:..|.... ..|
Zfish     4 CIAVFVLL-----VAVHCEEL-FNGDQVLRIHAESKDHIQVLKELEKDSGLDFWTHGFSTERPVD 62

  Fly    69 IQIIVAPH----KVPDFLEILGKSEIKYELQSRDVQKSLD-EIDEKVA--IKGRATTAYNWAQYY 126
            :::   ||    .|.|||:   ::.|.:.:...:||:.|| |..|.|:  ...|.|.::|:|.|:
Zfish    63 VRV---PHASLYAVKDFLK---ENNISFSVMINNVQELLDRERAEMVSNTEMERNTKSFNFAAYH 121

  Fly   127 ELDDTYAWLQSLAQTNPGVVTLIEGGKTYQGRSILGVKITKGGETINGKAKPGIFLEAGIHAREW 191
            :||..|:::.:|..::..:::.::.|.||:.|.:..:|.:.|||.     ||.|:::||||||||
Zfish   122 DLDTIYSFMDTLVASHSNLISKVKIGSTYENRPMYVLKFSTGGEN-----KPAIWIDAGIHAREW 181

  Fly   192 IAPAAATFIINQLLTSEVENIKELAEN----YTWYVLPHANPDGYVYTHTT----NRLWRKTR-- 246
            ::.|:|.:|.:::.|...|| :.||.|    ...|::..|||||||::|.|    :|||||:|
Zfish   182 VSHASAVWIADRIATDFKEN-RALARNVLSKMDIYLMIVANPDGYVFSHLTVRPFHRLWRKSRSV 245

  Fly   247 TPYGSCFGADPNRNWGFHWNEVGASSSACSDTYAGPSAFSEIETLSLSKFIEGLKGKVQLYLSLH 311
            |...:|.|.|.|||:...::..|||...|::.|.||||.||||..:::.||.. .|..:.:::||
Zfish   246 TSNPNCPGVDLNRNFDAEFSGPGASDDPCAEDYRGPSAHSEIEVTNIADFILS-HGNFKSFMTLH 309

  Fly   312 AYSQYLLYPYGHT-SDLPDNVADFEKVFDASIAAVNKRYGTTYTGGNIYDAIYPAAGASVDWAYG 375
            ||||.|:||||:| |:.||. .|...|...:..|:|..:||.|..|:|:..|..|:||||||||
Zfish   310 AYSQLLMYPYGYTGSNAPDQ-PDLHDVATQANKALNSWHGTIYKVGSIFHTIEQASGASVDWAY- 372

  Fly   376 TQDVRMAFCYELRPSSTSYLTGFKLPAEQIVPASEE 411
            ...::..|.:|||.:. .|  ||.|||:|||..:.|
Zfish   373 QHGIKYCFAFELRDTG-EY--GFLLPADQIVSTARE 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17633	NP_609310.2	MpaA	7..374	CDD:225421	136/386 (35%)
		Propep_M14	34..105	CDD:280416	20/76 (26%)
		M14_CP_A-B_like	125..423	CDD:199844	120/298 (40%)
cpa2	NP_001003446.2	Propep_M14	27..97	CDD:280416	19/75 (25%)
cpa2	NP_001003446.2	Peptidase_M14_like	115..420	CDD:299699	122/303 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593493
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.780