DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17633 and cpa5

DIOPT Version :9

Sequence 1:	NP_609310.2	Gene:	CG17633 / 34297	FlyBaseID:	FBgn0032144	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_954965.1	Gene:	cpa5 / 246092	ZFINID:	ZDB-GENE-020514-1	Length:	419	Species:	Danio rerio

Alignment Length:	429	Identity:	126/429 - (29%)
Similarity:	241/429 - (56%)	Gaps:	24/429 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLAIVASASVSAERVRYDNYRMYKVNSENAKQLEVLKDLEGSSDSI---MFLDGVHLVGADIQII 72
            ||.::|.......:..::..:::::..::..|:::||:|....:.:   ::::.: |....:.:.
Zfish     4 LLVLIALFVAVFGKKTFEGDQVFRITPKDEAQIDLLKELTEEGEHLGLSVWMEPI-LESLPLDLH 67

  Fly    73 VAPHKVPDFLEILGKSEIKYELQSRDVQKSLDEIDEKVAIK----GRATTAYNWAQYYELDDTYA 133
            |..|.:......|..::|.|.:...:||:.||: :::..:|    .|:|..:.:..|::|:...:
Zfish    68 VPFHSLQAVRAFLAYNQIPYHIMIENVQELLDD-EQRDMVKYRGLARSTDDFVYTTYHDLNSINS 131

  Fly   134 WLQSLAQTNPGVVTLIEGGKTYQGRSILGVKITKGGETINGKAKPGIFLEAGIHAREWIAPAAAT 198
            ::..|...|..:|:.:..|::|:.|.:..:|.:.|..      :|||:::.|||:|||:..|:..
Zfish   132 FMDMLVAENRNMVSKVVIGQSYEKRPLNVLKFSTGAN------RPGIWIDTGIHSREWVTQASGV 190

  Fly   199 FIINQLLTSEVEN--IKELAENYTWYVLPHANPDGYVYTHTTNRLWRKTR--TPYGSCFGADPNR 259
            :...:::.....:  :.::..::..::....||||:|||||.:|:|||||  .|..||.|.||||
Zfish   191 WFAKKIVKDYGRDPVLTDILNSHDIFLEIVTNPDGFVYTHTKDRMWRKTRKPNPGSSCVGVDPNR 255

  Fly   260 NWGFHWNEVGASSSACSDTYAGPSAFSEIETLSLSKFIEGLKGKVQLYLSLHAYSQYLLYPYGHT 324
            ||...:...|:|::.|::||.||||.||.|..::..|::. .||::.::|:|:|||.||||||:|
Zfish   256 NWDAGFGGGGSSNNPCTETYRGPSAHSEPEVKAIVDFVKS-HGKIKAFVSIHSYSQMLLYPYGYT 319

  Fly   325 SDLPDNVADFEKVFDASIAAVNKRYGTTYTGGNIYDAIYPAAGASVDWAYGTQDVRMAFCYELRP 389
            .....:.|:..:|...:|.::...|.|.||.|:|...||.|:|.::||.| .|.::.::.:|||.
Zfish   320 YTAAKDKAELHEVARKAITSLQSLYNTRYTYGSIITTIYQASGGTIDWTY-NQGIKYSYTFELRD 383

  Fly   390 SSTSYLTGFKLPAEQIVPASEELLDSIVAMATEVKSLGY 428
            :..   .||.|||.||||.:||...:::|:....|:..|
Zfish   384 TGR---YGFILPANQIVPTAEETWLALMAIMEHTKNNPY 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17633	NP_609310.2	MpaA	7..374	CDD:225421	107/373 (29%)
		Propep_M14	34..105	CDD:280416	13/73 (18%)
		M14_CP_A-B_like	125..423	CDD:199844	104/301 (35%)
cpa5	NP_954965.1	Propep_M14	27..100	CDD:280416	13/73 (18%)
cpa5	NP_954965.1	Peptidase_M14_like	118..417	CDD:299699	105/309 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593530
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55609
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.780