DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17633 and T06A4.1

DIOPT Version :9

Sequence 1:	NP_609310.2	Gene:	CG17633 / 34297	FlyBaseID:	FBgn0032144	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_871809.1	Gene:	T06A4.1 / 171669	WormBaseID:	WBGene00020281	Length:	606	Species:	Caenorhabditis elegans

Alignment Length:	447	Identity:	147/447 - (32%)
Similarity:	234/447 - (52%)	Gaps:	36/447 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLNKCLLF--ALLAIVASASVSAERVRYDNYRMYKVNSENAKQLEVLKDL--EGSSDSIMFLDG 61
            |.|...||.  |....:.:...:.:...|.|:::.::|.|....::.|:.|  :.|...:.|...
Worm     1 MRLPSILLIFGAFFGFLGAIHNTDDNAGYHNFKLIRINPETEGSVKYLRSLYEDPSPYELDFWQP 65

  Fly    62 VHLVGADIQIIVAPHKVPDFLEILGKSEIKYELQSRDVQKSLDEIDEKVAIK-GRATTAYNWAQY 125
            ...:||.:.:.|||...|.|::.|...:|.|.:...|:.|:::  :|:.:.| ......:.:.:|
Worm    66 PTNIGAIVDLTVAPADAPRFVKDLESKKISYIVAVNDLSKAIE--NERGSDKFYNPVAGFAYDKY 128

  Fly   126 YELDDTYAWLQSLAQTNPGVVTLIEGGKTYQGRSILGVKITKGGETINGKAKP-----GIFLEAG 185
            ..|::....::.|.:..|.::|||:.|::::.|::|.:|||       ||..|     .::::||
Worm   129 NSLEEIQTEMKRLKKEYPTMITLIDIGQSHENRTLLVMKIT-------GKRNPLGSKISMWIDAG 186

  Fly   186 IHAREWIAPAAATFIINQLLTSEVEN---IKELAENYTWYVLPHANPDGYVYTHTTNRLWRKTRT 247
            ||||||||||.|.:|.::||.. .||   :.:|.::..:|:||..|||||.|:...||:|||.|:
Worm   187 IHAREWIAPATAMYIAHELLLG-YENDATVAKLMDHIDFYILPVMNPDGYEYSREKNRMWRKNRS 250

  Fly   248 PYG---------SCFGADPNRNWGFHWNEVGASSSACSDTYAGPSAFSEIETLSLSKFIEGLKGK 303
            |..         .|.|.|.|||:.:.|...|:||..|.|||.|.:||||.|:.::..|:|  :..
Worm   251 PAKCARQTFSTVCCSGVDLNRNFDWFWASTGSSSDPCHDTYHGSAAFSEPESQAVRDFLE--QNT 313

  Fly   304 VQLYLSLHAYSQYLLYPYGH--TSDLPDNVADFEKVFDASIAAVNKRYGTTYTGGNIYDAIYPAA 366
            .:.::|||:|||..|.||||  .|...|.......:...:..|:.:.|||.|..|...|.:|.|:
Worm   314 PEAFISLHSYSQMWLIPYGHRKQSYPQDYHTGLRPLALRATKALYELYGTKYQVGTGADLMYEAS 378

  Fly   367 GASVDWAYGTQDVRMAFCYELRPSSTSYLTGFKLPAEQIVPASEELLDSIVAMATEV 423
            |.|.|||.|...|..|:..||||.:|....||.||..:|||...|..:||..:|.|:
Worm   379 GGSHDWAKGQLKVPYAYLIELRPKNTMMGHGFLLPEREIVPTGLETFESIKVVADEL 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17633	NP_609310.2	MpaA	7..374	CDD:225421	124/390 (32%)
		Propep_M14	34..105	CDD:280416	18/72 (25%)
		M14_CP_A-B_like	125..423	CDD:199844	119/316 (38%)
T06A4.1	NP_871809.1	Propep_M14	40..110	CDD:366995	17/71 (24%)
		M14_CP_A-B_like	128..435	CDD:349433	119/316 (38%)
		ShK	568..602	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165686
Domainoid	1	1.000	224	1.000	Domainoid score	I1450
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm4737
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.830