DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17633 and CPO

DIOPT Version :9

Sequence 1:	NP_609310.2	Gene:	CG17633 / 34297	FlyBaseID:	FBgn0032144	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_775100.1	Gene:	CPO / 130749	HGNCID:	21011	Length:	374	Species:	Homo sapiens

Alignment Length:	324	Identity:	118/324 - (36%)
Similarity:	190/324 - (58%)	Gaps:	18/324 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 IDEKVAIKGRATTAYNWAQYYELDDTYAWLQSLAQTNPGVVTLIEGGKTYQGRSILGVKITKGGE 170
            :|:.|:.....|.:||  .|:.:.:.|.|::.:::....|||....|.||:...:..:||::.
Human    33 VDKSVSPWSLETYSYN--IYHPMGEIYEWMREISEKYKEVVTQHFLGVTYETHPMYYLKISQP-- 93

  Fly   171 TINGKAKPGIFLEAGIHAREWIAPAAATFIINQLLTSEVEN--IKELAENYTWYVLPHANPDGYV 233
              :|..|..|:::.|||||||||||...:.:.::|.:..:|  |::|..|..:||||..|.|||:
Human    94 --SGNPKKIIWMDCGIHAREWIAPAFCQWFVKEILQNHKDNSSIRKLLRNLDFYVLPVLNIDGYI 156

  Fly   234 YTHTTNRLWRKTRTPY--GSCFGADPNRNWGFHWNEVGASSSACSDTYAGPSAFSEIETLSLSKF 296
            ||.||:|||||:|:|:  |:|||.|.|||:...|..:|||.:....|:.|....||.||.:::.|
Human   157 YTWTTDRLWRKSRSPHNNGTCFGTDLNRNFNASWCSIGASRNCQDQTFCGTGPVSEPETKAVASF 221

  Fly   297 IEGLKGKVQLYLSLHAYSQYLLYPYGHTSDLPDNVADFEKVFDASIAAVNKRYGTTYTGGNIYDA 361
            ||..|..:..:|::|:|.|.:|.|||:|.:...|..:..:|...:..|:..:|||.|..|:..|.
Human   222 IESKKDDILCFLTMHSYGQLILTPYGYTKNKSSNHPEMIQVGQKAANALKAKYGTNYRVGSSADI 286

  Fly   362 IYPAAGASVDWAYGTQDVRMAFCY--ELRPSSTSYLTGFKLPAEQIVPASEELLDSIVAMATEV 423
            :|.::|:|.|||   :|:.:.|.|  |||.|.|   .||.||..||.|..||.:::::::..:|
Human   287 LYASSGSSRDWA---RDIGIPFSYTFELRDSGT---YGFVLPEAQIQPTCEETMEAVLSVLDDV 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17633	NP_609310.2	MpaA	7..374	CDD:225421	99/271 (37%)
		Propep_M14	34..105	CDD:280416
		M14_CP_A-B_like	125..423	CDD:199844	112/303 (37%)
CPO	NP_775100.1	M14_CPO	47..344	CDD:133105	114/308 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157743
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm8518
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.780