DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4017 and ECM14

DIOPT Version :9

Sequence 1:	NP_609309.1	Gene:	CG4017 / 34296	FlyBaseID:	FBgn0032143	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_012000.1	Gene:	ECM14 / 856533	SGDID:	S000001174	Length:	430	Species:	Saccharomyces cerevisiae

Alignment Length:	453	Identity:	134/453 - (29%)
Similarity:	210/453 - (46%)	Gaps:	94/453 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLLLLSVNILIFCLAERQRFDNYKVYRVSPVKANQLEGLRSLEANSEDALVLNNLHLGPTDFLVA 68
            |.:||:|...:..|.|  .:..|.|||.:              :::...||.:         ::|
Yeast    12 LFVLLAVTGAVQGLQE--DYSEYAVYRFT--------------SDNYSTLVRD---------VIA 51

  Fly    69 P---DFD-----GTF--LKLVKD-----------LDLSPELIDANAQTSLSLDIEPIADANRRSD 112
            |   |:|     ..|  :||.|:           :|...|||.....||..:..|.....|  ..
Yeast    52 PLTDDYDVWTRSNNFIDIKLPKEIGEQINDGQVIIDNMNELIQNTLPTSQMMAREQAVFEN--DY 114

  Fly   113 DYSWSEYHELNDTHRWMQNLVGKYPDVVSVFVAGQSYEGRELLGLRINHN--DGRAEKQSIFLEA 175
            |:.::||.:|:..:.|:..|...:|.:|:|...|:::|||||..|.|:.|  :...||::|.:..
Yeast   115 DFFFNEYRDLDTIYMWLDLLERSFPSLVAVEHLGRTFEGRELKALHISGNKPESNPEKKTIVITG 179

  Fly   176 GMHAREWIGPATATYFANELLS---SQQQEIMNLARSYVWYILPHANPDGYVYTHKTNRMWRKTR 237
            |:||||||..:|..:...:||:   |.::|...| ....:.::|..|||||.||...:|:|||.|
Yeast   180 GIHAREWISVSTVCWALYQLLNRYGSSKKETKYL-DDLDFLVIPVFNPDGYAYTWSHDRLWRKNR 243

  Fly   238 S----PQDKNCVGTDPNRNWDFHWREVGASSDPCSESYAGPKAFSEPEVQTLSQFLKSVPE---- 294
            .    ||   |:|.|.:.::.|.|.:  |.:..|||.|:|...|   |....|.:.|.:.|
Yeast   244 QRTHVPQ---CLGIDIDHSFGFQWEK--AHTHACSEEYSGETPF---EAWEASAWYKYINETKGD 300

  Fly   295 -PMFMFLSLHSFSQLLLYPYGHT-SALPENHRQLEQIFNTAVGAMKRRYGTRYTGGNVYDA---- 353
             .::.::.:||:||.:||||.:: .|||   |.||.:...:.|..|   ..|...|..||.
Yeast   301 YKIYGYIDMHSYSQEILYPYAYSCDALP---RDLENLLELSYGLSK---AIRSKSGRNYDVISAC 359

  Fly   354 ------IYP--AAGSSMDWAYGVLNVKYSFTYELRPSGYSFWTGFRLPAAQIIPTGQETTDSL 408
                  |:|  .|||::|:.|. ....::|..:||.:|..   ||.||...|.|.|:||..:|
Yeast   360 KDRGSDIFPGLGAGSALDFMYH-HRAHWAFQLKLRDTGNH---GFLLPPENIKPVGKETYAAL 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4017	NP_609309.1	Propep_M14	30..97	CDD:280416	16/87 (18%)
CG4017	NP_609309.1	M14_CP_A-B_like	119..415	CDD:199844	104/317 (33%)
ECM14	NP_012000.1	M14_CP_A-B_like	121..425	CDD:349433	104/317 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I805
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1851
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		otm46499
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
TreeFam	0	0.000	Not matched by this tool.
	10	9.790