DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4017 and Cpb1

DIOPT Version :9

Sequence 1:	NP_609309.1	Gene:	CG4017 / 34296	FlyBaseID:	FBgn0032143	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_083982.1	Gene:	Cpb1 / 76703	MGIID:	1923953	Length:	415	Species:	Mus musculus

Alignment Length:	452	Identity:	156/452 - (34%)
Similarity:	233/452 - (51%)	Gaps:	68/452 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLLLLLLSVNILIFCLAERQRFDNYKVYRVS-----------------------PVKANQLEGL 42
            |.|||.|:||.:   ..|..:.||..:|:|||                       |..|.|::.|
Mouse     1 MLLLLALVSVAL---AHASEENFDGNRVFRVSVHDEDDVSLIQELANTKQIDFWKPDSATQVKPL 62

  Fly    43 RSLE--ANSEDALVLNNLHLGPTDFLVAPDFDGTFLKLVKDLDLSPELIDANAQTSLSLDIEPIA 105
            .:::  ..:||.:.:.|                    .:::.::..|::.:|.:..|    |...
Mouse    63 TTVDFHVKAEDVVDVEN--------------------FLEENEVLYEVLISNVKHIL----ESQF 103

  Fly   106 DANRRSDDYSWSEYHELNDTHRWMQNLVGKYPDVVSVFVAGQSYEGRELLGLRINHNDGRAEKQS 170
            |::.|:..:|:::|:.......|:|.:....||:||..|.|.::|||.:..|:|..:  |..|.:
Mouse   104 DSHTRASGHSYTKYNNWETIEAWIQQVANDNPDLVSKRVIGTTFEGRNMYVLKIGKD--RPNKPA 166

  Fly   171 IFLEAGMHAREWIGPATATYFANELLSSQQQEI--MNLARSYVWYILPHANPDGYVYTHKTNRMW 233
            .|::.|.||||||.||...:|..|.:.:.:|||  ..|.....:|:||..|.||||||...:|||
Mouse   167 FFIDCGFHAREWISPAFCQWFVREAVRTYKQEIHMKRLLDELDFYVLPVVNIDGYVYTWAKDRMW 231

  Fly   234 RKTRS-PQDKNCVGTDPNRNWDFHWREVGASSDPCSESYAGPKAFSEPEVQTLSQFLKSVPEPMF 297
            ||||| ....:|.|.|||||:|..|.|||||..|||::|.||...||.|.:.|:.|::.....:.
Mouse   232 RKTRSTTAGSSCFGVDPNRNFDAGWCEVGASRSPCSDTYCGPTPESEKETKALADFIRQNLSSIK 296

  Fly   298 MFLSLHSFSQLLLYPYGHTSALPENHRQLEQIFNTAVGAMKRRYGTRYTGGNVYDAIYPAAGSSM 362
            .:|::||:||::||||.:...||||:.:|..:...|...:...:||:||.|.....||||||.|.
Mouse   297 AYLTVHSYSQMMLYPYSYDYKLPENYEELNALVKGAAKELSTLHGTKYTYGPGATTIYPAAGGSD 361

  Fly   363 DWAYGVLNVKYSFTYELRPSGYSFWTGFRLPAAQIIPTGQETTDSLVEMIKAAAQIEGYKIE 424
            ||||. ..:|||||:|||..|:   .||.||.:||..|.:||       :.|...|..|.:|
Mouse   362 DWAYD-QGIKYSFTFELRDKGF---FGFLLPESQIRQTCEET-------MLAVKYIANYVLE 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4017	NP_609309.1	Propep_M14	30..97	CDD:280416	12/91 (13%)
CG4017	NP_609309.1	M14_CP_A-B_like	119..415	CDD:199844	124/298 (42%)
Cpb1	NP_083982.1	Propep_M14	31..102	CDD:396700	11/94 (12%)
Cpb1	NP_083982.1	M14_CPB	112..411	CDD:349443	128/311 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848069
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68127
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1851
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm8747
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.630