DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4017 and Cpa4

DIOPT Version :9

Sequence 1:	NP_609309.1	Gene:	CG4017 / 34296	FlyBaseID:	FBgn0032143	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_017177239.1	Gene:	Cpa4 / 71791	MGIID:	1919041	Length:	469	Species:	Mus musculus

Alignment Length:	422	Identity:	150/422 - (35%)
Similarity:	229/422 - (54%)	Gaps:	44/422 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLLLLSVNILIFCLAERQRFDNYKVYRVSPVKANQLEGLRSLEANSEDALVLNNLHL-------- 60
            ||....:.|:.|.|.    |...:|:|::....:::..|..|         :|:.||
Mouse    55 LLASRKLTIIFFSLP----FSRDQVFRINVRNGDEIRKLTEL---------VNSDHLKLSVWKSP 106

  Fly    61 ----GPTDFLVAPDFD----GTFLKLVKDLDLSPELIDANAQTSLSLDIEPIA--DANRRSDDYS 115
                .|.|.|| |...    .:||| .:.||.|..:.|  .|..|..:.|.:.  :...||.|::
Mouse   107 STFDRPVDILV-PSVSLLPVKSFLK-SQGLDYSVTIED--LQALLDNEDEEMQHNEGIERSGDFN 167

  Fly   116 WSEYHELNDTHRWMQNLVGKYPDVVSVFVAGQSYEGRELLGLRINHNDGRAEKQSIFLEAGMHAR 180
            :..||.|...:..|.::...:|::||....|:::|.|.:..|:.:...|: ::.:|:|.||:|||
Mouse   168 YGAYHPLEAIYHEMDSIATDFPELVSRVKIGETFEKRPMYVLKFSTGGGK-KRPAIWLNAGIHAR 231

  Fly   181 EWIGPATATYFANELLSSQQQE--IMNLARSYVWYILPHANPDGYVYTHKTNRMWRKTRSPQ-DK 242
            |||..|||.:.|.::::..:::  |.::.:....::||.|||||||||...||:||||||.. ..
Mouse   232 EWISQATAIWTARKIVTDYKKDPAITSILKKVDIFLLPVANPDGYVYTQSQNRLWRKTRSRNPGS 296

  Fly   243 NCVGTDPNRNWDFHWREVGASSDPCSESYAGPKAFSEPEVQTLSQFLKSVPEPMFMFLSLHSFSQ 307
            .|||.||||||:..:...|.|.:||||.|.|....||.||:::..|::.... ...|:.|||:||
Mouse   297 RCVGADPNRNWNASFAGEGTSDNPCSEVYHGSHPNSEVEVKSVVDFIQKHGN-FKCFIDLHSYSQ 360

  Fly   308 LLLYPYGHTSALPENHRQLEQIFNTAVGAMKRRYGTRYTGGNVYDAIYPAAGSSMDWAYGVLNVK 372
            ||:||||:|.....:..:|:.:...|..|:....||:|..|.....:|||:|||:||||. ..:|
Mouse   361 LLMYPYGYTVKKAPDAEELDDVARNAAQALASLSGTKYRVGPTCTTVYPASGSSVDWAYD-NGIK 424

  Fly   373 YSFTYELRPSGYSFWTGFRLPAAQIIPTGQET 404
            |:||:|||.:||   .||.|||:|||||.:||
Mouse   425 YAFTFELRDTGY---YGFLLPASQIIPTAEET 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4017	NP_609309.1	Propep_M14	30..97	CDD:280416	19/82 (23%)
CG4017	NP_609309.1	M14_CP_A-B_like	119..415	CDD:199844	119/289 (41%)
Cpa4	XP_017177239.1	Propep_M14	81..150	CDD:366995	19/81 (23%)
Cpa4	XP_017177239.1	M14_CPA	166..467	CDD:349442	119/294 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848041
Domainoid	1	1.000	237	1.000	Domainoid score	I2307
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm8747
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.780