DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4017 and AGBL5

DIOPT Version :9

Sequence 1:	NP_609309.1	Gene:	CG4017 / 34296	FlyBaseID:	FBgn0032143	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_068603.4	Gene:	AGBL5 / 60509	HGNCID:	26147	Length:	886	Species:	Homo sapiens

Alignment Length:	395	Identity:	71/395 - (17%)
Similarity:	120/395 - (30%)	Gaps:	167/395 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 YSWSEYHELNDTHRWMQNLVGKYP----------DVVSVFVAGQSYEGRELL-----GLRIN--- 160
            :|:|:..||      :..|..::|          |.:        |..||||     |||::
Human   159 FSYSDCQEL------LNQLDQRFPENHPTHSSPLDTI--------YYHRELLCYSLDGLRVDLLT 209

  Fly   161 ---------HNDGRAE----------------KQSIFLEAGMHAREWIGPATATYFANELLSSQQ 200
                     ..:.|.|                |:..||.:.:|..|.........|.:.:|....
Human   210 ITSCHGLREDREPRLEQLFPDTSTPRPFRFAGKRIFFLSSRVHPGETPSSFVFNGFLDFILRPDD 274

  Fly   201 QEIMNLARSYVWYILPHANPDGYVYTH--------KTNRMWRK---------------------- 235
            .....|.|.:|:.::|..||||.|..|        ..||.:.|
Human   275 PRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAVLHPAIYGAKAVLLYHHVH 339

  Fly   236 -------TRSPQDKNCVGTDP-----------------NRNWDFH----WREVGASSDPCSESYA 272
                   :...|..:|:..|.                 ..:.|.|    |::...:....:..:.
Human   340 SRLNSQSSSEHQPSSCLPPDAPVSDLEKANNLQNEAQCGHSADRHNAEAWKQTEPAEQKLNSVWI 404

  Fly   273 GPKAFSEPEVQTLSQFLKSVPEP-------MFMFLSLHSF-SQLLLYPYGHTSALPENHRQLEQI 329
            .|:..:..|        :|.|:.       :..::.||.. |:...:.||  ::..:...|:|.:
Human   405 MPQQSAGLE--------ESAPDTIPPKESGVAYYVDLHGHASKRGCFMYG--NSFSDESTQVENM 459

  Fly   330 -------FNTA-------------VGAMKRRYGTRYTG-GNVYDAIYPAAGSSMDWAYGVLNVKY 373
                   .|:|             :.|..||.|....| |.|  |||.|:|           :.:
Human   460 LYPKLISLNSAHFDFQGCNFSEKNMYARDRRDGQSKEGSGRV--AIYKASG-----------IIH 511

  Fly   374 SFTYE 378
            |:|.|
Human   512 SYTLE 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4017	NP_609309.1	Propep_M14	30..97	CDD:280416
CG4017	NP_609309.1	M14_CP_A-B_like	119..415	CDD:199844	69/390 (18%)
AGBL5	NP_068603.4	M14_AGBL5_like	176..568	CDD:199860	66/372 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..364		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	605..734
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..848
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810